Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.62 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | ROS1 | P08922 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5431179 | 0.87 | ROCK2 (0.48) | ROCK2ROCK1KDRMAPK1 | |
| SCHEMBL5320011 | 0.87 | ROCK2 (0.48) | ROCK2ROCK1KDRMAPK1 | |
| SCHEMBL5341899 | 0.87 | ROCK2 (0.48) | ROCK2ROCK1KDRMAPK1 | |
| SCHEMBL5342613 | 0.86 | VCP (0.50) | ROCK2ROCK1JAK2KDRPIM1 | |
| SCHEMBL5344353 | 0.86 | ROCK2 (0.50) | ROCK2ROCK1KDRDYRK1ANPC1 | |
| SCHEMBL5333863 | 0.85 | VCP (0.58) | ROCK2ROCK1KDRPRKAA1IMPDH2 | |
| SCHEMBL5333205 | 0.85 | IMPDH2 (0.53) | ROCK2ROCK1KDRIMPDH2VCP | |
| SCHEMBL5319078 | 0.85 | ROCK2 (0.52) | ROCK2ROCK1KDRPRKD3MAP4K4 | |
| SCHEMBL5336433 | 0.83 | MKNK1 (0.51) | ROCK2ROCK1KDRRAB9AIMPDH2 | |
| SCHEMBL5336680 | 0.83 | IMPDH2 (0.59) | ROCK1KDRGSK3BDYRK3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |