Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | CBFB | Q13951 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533960 | 0.89 | CYP2D6 (0.42) | SLC6A4HTR1ACYP2D6KDM4EALDH1A1 | |
| SCHEMBL925088 | 0.87 | KDM4E (0.38) | SLC6A4HTR1ACYP2D6SLC6A2SLC6A3 | |
| SCHEMBL8257155 | 0.84 | SLC6A4 (0.40) | SLC6A4HTR1ACYP2D6SLC6A2SMN1; SMN2 | |
| SCHEMBL8259521 | 0.80 | SLC6A4 (0.41) | SLC6A4HTR1ACYP2D6SMN1; SMN2CHEK2 | |
| SCHEMBL533873 | 0.80 | SLC6A4 (0.41) | SLC6A4HTR1ACYP2D6SMN1; SMN2CHEK2 | |
| SCHEMBL14255244 | 0.78 | HDAC1 (0.44) | SLC6A4HTR1ACYP2D6CYP3A4HDAC1 | |
| SCHEMBL533934 | 0.78 | ALDH1A1 (0.42) | CYP2D6CNR2MEN1ALDH1A1KMT2A | |
| SCHEMBL534650 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL555957 | 0.75 | MTNR1A (0.38) | SLC6A4HTR1ACYP2D6SMN1; SMN2CHEK2 | |
| SCHEMBL6401187 | 0.73 | CYP2D6 (0.51) | SLC6A4HTR1ACYP2D6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | SLC6A4 2645/4885HTR1A 3606/4885CYP2D6 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.