Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533934 | 0.83 | ALDH1A1 (0.42) | CYP2D6PPARG | |
| SCHEMBL533960 | 0.76 | CYP2D6 (0.42) | HTR1ACYP2D6SLC6A4PPARGBRD4 | |
| SCHEMBL27893911 | 0.76 | MTNR1A (0.39) | MTNR1AMTNR1BCA12CA1CA2 | |
| SCHEMBL534207 | 0.75 | SLC6A4 (0.40) | HTR1ACYP2D6SLC6A4HDAC1CHEK2 | |
| SCHEMBL8257155 | 0.74 | SLC6A4 (0.40) | HTR1ACYP2D6SLC6A4BRD4CHEK2 | |
| SCHEMBL555956 | 0.73 | PPARG (0.37) | HTR1ACYP2D6SLC6A4PPARGCHEK2 | |
| SCHEMBL6987122 | 0.73 | MEN1 (0.47) | MTNR1AMTNR1BFFAR1 | |
| SCHEMBL8259521 | 0.72 | SLC6A4 (0.41) | HTR1ACYP2D6SLC6A4BRD4CHEK2 | |
| SCHEMBL533873 | 0.72 | SLC6A4 (0.41) | HTR1ACYP2D6SLC6A4BRD4CHEK2 | |
| SCHEMBL16294203 | 0.72 | POLB (0.48) | MTNR1AMTNR1BHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MTNR1A 2293/4885MTNR1B 1285/4885HTR1A 3606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.