Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 4/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28680653 | 0.84 | F11 (0.49) | ANPEPLAP3LIPGF11F2 | |
| SCHEMBL534423 | 0.76 | CYP1A2 (0.44) | ANPEPLAP3LIPGF11F2 | |
| SCHEMBL14934883 | 0.75 | CXCR2 (0.39) | LIPGF11F2PRSS1PRSS2 | |
| SCHEMBL1805601 | 0.73 | PPARA (0.43) | KMT2ACTSKSRREPHX1ALPI | |
| SCHEMBL29179974 | 0.73 | CXCR2 (0.40) | ANPEPLAP3LIPGF11F2 | |
| SCHEMBL20494027 | 0.73 | CXCR2 (0.41) | LIPGF11F2PRSS1PRSS2 | |
| SCHEMBL902458 | 0.72 | LIPG (0.49) | ANPEPLAP3LIPGF11F2 | |
| SCHEMBL4158920 | 0.71 | AKR1B1 (0.46) | LIPGCXCR2 | |
| SCHEMBL28864980 | 0.71 | LIPE (0.34) | LIPGF11F2PRSS1PRSS2 | |
| SCHEMBL9280171 | 0.71 | CTSK (0.55) | LAP3CTSKSRREPHX1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2011057382-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES USEFUL AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2011-05-19 | — | — | WO | disclosed |