Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385884 | 0.88 | TSHR (0.44) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL5351821 | 0.85 | — | — | |
| SCHEMBL18274688 | 0.84 | ALDH1A1 (0.38) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL6560315 | 0.81 | MEN1 (0.55) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL20913720 | 0.81 | MEN1 (0.55) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL822271 | 0.81 | MEN1 (0.55) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL28519535 | 0.80 | NAAA (0.47) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL26669487 | 0.80 | NAAA (0.47) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL243060 | 0.80 | ADRA2A (0.43) | TSHRALDH1A1TP53HIF1AADRA2A | |
| SCHEMBL26479100 | 0.78 | TSHR (0.34) | TSHRALDH1A1TP53HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279304-B2 | Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-10-09 | — | — | US | claimed |
| US-20020192773-A1 | Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2002-12-19 | — | — | US | claimed |
| US-7279304-B2 | Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-10-09 | — | — | US | disclosed |
| WO-2003040094-A9 | METHODS FOR PREPARATION OF MACROCYCLIC MOLECULES MACROCYCLIC MOLECULES PREPARED THEREBY AND SUBSTRATES AND SOLID SUPPORTS FOR USE THEREIN | HARVARD COLLEGE (US) | 2004-04-15 | — | — | WO | disclosed |
| US-20030158377-A1 | Methods for preparation of macrocyclic molecules macrocyclic molecules prepared thereby and substrates and solid supports for use therein | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2003-08-21 | — | — | US | disclosed |
| WO-2003040094-A2 | METHODS FOR PREPARATION OF MACROCYCLIC MOLECULES MACROCYCLIC MOLECULES PREPARED THEREBY AND SUBSTRATES AND SOLID SUPPORTS FOR USE THEREIN | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2003-05-15 | — | — | WO | disclosed |
| US-20020192773-A1 | Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2002-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158377-A1 | Methods for preparation of macrocyclic molecules macrocyclic molecules prepared thereby and substrates and solid supports for use therein | VIP, ZKSCAN2, TEC | TSHR 2263/4885ALDH1A1 4602/4885TP53 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.