Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593793 | 0.95 | ADRA2A (0.42) | ADRA2ADRD2ADRA2BADRA2CDRD1 | |
| SCHEMBL12949415 | 0.79 | CHRM5 (0.43) | ADRA2CKDM4E | |
| Pimeclone SCHEMBL545058 | 0.78 | CHRM5 (0.47) | ADRA2CKDM4E | |
| Pimeclone SCHEMBL4551919 | 0.76 | CHRM5 (0.45) | ADRA2CKDM4E | |
| SCHEMBL8788671 | 0.74 | ACHE (0.50) | GAAALDH1A1HRH3 | |
| SCHEMBL12014396 | 0.73 | ADRA2A (0.41) | ADRA2ADRD2ADRA2BADRA2CDRD1 | |
| SCHEMBL19565928 | 0.71 | HSP90AA1 (0.36) | ADRA2ADRD2ADRA2BADRA2CDRD1 | |
| SCHEMBL2182422 | 0.71 | HSP90AA1 (0.62) | ADRA2ADRD2ADRA2BADRA2CDRD1 | |
| Hydrochloric Acid SCHEMBL19548511 | 0.70 | HSP90AA1 (0.38) | ADRA2ADRD2ADRA2BADRA2CDRD1 | |
| SCHEMBL11609558 | 0.69 | MGLL (0.45) | CYP1A2CYP2C19GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101168530-B | 1,4-dioxoquinoxaline formaldehyde dihydrazone with weed control activity and its preparation method and application | UNIV HUAZHONG AGRICULTURAL | 2011-02-09 | — | — | CN | disclosed |
| CN-101168530-A | 1,4-dioxoquinoxaline formaldehyde dihydrazone with weed control activity and its preparation method and application | UNIV HUAZHONG AGRICULTURAL (CN) | 2008-04-30 | — | — | CN | disclosed |
| US-7288650-B2 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2007-10-30 | — | — | US | disclosed |
| US-7074793-B2 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20060128780-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2006-06-15 | — | — | US | disclosed |
| US-6841567-B1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2005-01-11 | — | — | US | disclosed |
| US-20040186157-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2004-09-23 | — | — | US | disclosed |
| CN-1350537-A | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON INC (US) | 2002-05-22 | — | — | CN | disclosed |
| EP-1165562-A1 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | Cephalon, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000047583-A9 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | CEPHALON INC (US) | 2001-09-20 | — | — | WO | disclosed |
| WO-2000047583-A1 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | CEPHALON, INC. (US) | 2000-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186157-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | PIN1, PAICS, QPCT | ADRA2A 4145/4885DRD2 1669/4885ADRA2B 4289/4885 |
| US-20060128780-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | PIN1, PAICS, QPCT | ADRA2A 4145/4885DRD2 1669/4885ADRA2B 4289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.