Sugi Predict

Sugi Predict / Compounds / SCHEMBL5344941

SCHEMBL5344941

SCHEMBL5344941

O=c1oc2c(ccc3ccccc32)c(O)c1C1c2c(c3ccc4ccccc4c3oc2=O)OC1O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCG2 Q9UNQ0 4/20 0.42
▸ HPGD P15428 5/20 0.39
▸ ALDH1A1 P00352 4/20 0.39
▸ LMNA P02545 1/20 0.39
▸ CYP1B1 Q16678 5/20 0.38
▸ CYP1A1 P04798 4/20 0.38
▸ CYP1A2 P05177 4/20 0.38
▸ CYP3A4 P08684 2/20 0.38
▸ TSHR P16473 2/20 0.38
▸ CYP2C19 P33261 2/20 0.38
▸ PSMD14 O00487 1/20 0.38
▸ CSNK2A2 P19784 1/20 0.38
▸ CSNK2B P67870 1/20 0.38
▸ CSNK2A1 P68400 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ KDM4E B2RXH2 4/20 0.38
▸ MAPT P10636 2/20 0.38
▸ ARSA P15289 1/20 0.38
▸ CDC25A P30304 1/20 0.38
▸ CDC25C P30307 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5338619 0.83 PKLR (0.47) HPGDALDH1A1LMNACYP3A4CYP2C19
SCHEMBL5338654 0.81 ESR2 (0.38) KDM4EMCL1PRKDCADORA1NQO1
SCHEMBL5337992 0.81 TTR (0.34) TP53NQO1
SCHEMBL5340558 0.80 GABRA1 (0.34) MAPTKMT2ANQO1
SCHEMBL5345493 0.79 NQO1 (0.51) HPGDALDH1A1KDM4EMCL1HSD17B10
SCHEMBL5337618 0.79 ESR2 (0.49) HPGDALDH1A1LMNAKDM4EHSD17B10
SCHEMBL5341632 0.79 HIF1A (0.33) HPGDLMNACYP1A2CYP3A4TSHR
SCHEMBL5352117 0.78 NQO1 (0.53) HPGDALDH1A1LMNACYP1A2CYP3A4
SCHEMBL5341622 0.78 ABCG2 (0.42) ABCG2HPGDALDH1A1CYP1A1CYP1A2
SCHEMBL22655395 0.73 KMT2A (0.44) ABCG2HPGDALDH1A1LMNACYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7208518-B2 Substituted furochromene compounds of antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2007-04-24 — — US claimed
US-20060148890-A1 Substituted furochromene compounds of antiinflammatory action PLIVA-LSTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US claimed
US-7208518-B2 Substituted furochromene compounds of antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2007-04-24 — — US disclosed
US-7208518-B2 Substituted furochromene compounds of antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2007-04-24 — — US disclosed
US-7208518-B2 Substituted furochromene compounds of antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2007-04-24 — — US disclosed
US-20060148890-A1 Substituted furochromene compounds of antiinflammatory action PLIVA-LSTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060148890-A1 Substituted furochromene compounds of antiinflammatory action LTC4S, CYP11B2, CYP11B1 ABCG2 2211/4885HPGD 103/4885ALDH1A1 550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.