Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 11/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317466 | 0.90 | HDAC1 (0.45) | HDAC1HDAC8HDAC6ICMTPTPN2 | |
| SCHEMBL5342941 | 0.90 | PLA2G2A (0.51) | HDAC1HDAC8HDAC6ICMTPTPN2 | |
| SCHEMBL5337560 | 0.89 | HDAC6 (0.55) | HDAC1HDAC8HDAC6PTPN2PTPN1 | |
| SCHEMBL5320495 | 0.89 | CACNB4 (0.45) | HDAC1HDAC8HDAC6ICMTPTPN2 | |
| SCHEMBL5320802 | 0.89 | HDAC1 (0.44) | HDAC1HDAC8HDAC6ICMTPTPN2 | |
| SCHEMBL5339333 | 0.86 | PLA2G2A (0.54) | HDAC1HDAC8HDAC6ICMTPTPN2 | |
| SCHEMBL14466343 | 0.77 | ICMT (0.42) | HDAC1HDAC8HDAC6ICMTPLA2G2A | |
| SCHEMBL5343124 | 0.77 | PTPN1 (0.47) | PTPN2PTPN1PTPRC | |
| SCHEMBL5348172 | 0.76 | HDAC6 (0.48) | HDAC1HDAC8HDAC6HTR6 | |
| SCHEMBL5348177 | 0.76 | HDAC6 (0.46) | HDAC1HDAC8HDAC6PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | claimed |
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |