Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | CCR5 | P51681 | 3/20 | 0.35 |
| ▸ | CCR8 | P51685 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688602 | 0.86 | LMNA (0.51) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL2046270 | 0.74 | LMNA (0.59) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL10923588 | 0.71 | LMNA (0.78) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL9339299 | 0.71 | — | — | |
| SCHEMBL29199199 | 0.69 | — | — | |
| SCHEMBL6413480 | 0.69 | MAPK10 (0.41) | LMNAKDM4ETP53HTTSMN1; SMN2 | |
| SCHEMBL27375364 | 0.68 | LMNA (0.96) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL5592200 | 0.68 | LMNA (0.47) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL27975347 | 0.68 | LMNA (0.56) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL7368978 | 0.68 | LMNA (0.61) | LMNACCR1CCR5CCR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4740152-B2 | — | — | 2011-08-03 | — | — | JP | claimed |
| EP-1097135-B1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 2008-05-07 | — | — | EP | claimed |
| US-20070254874-A1 | Modulators of Preripheral 5-Ht Receptors | BIO-MEDISINSK INNOVASJON (NO) | 2007-11-01 | — | — | US | claimed |
| EP-1701951-A2 | MODULATORS OF PERIPHERAL 5-HT RECEPTORS | Bio-Medisinsk Innovasjon AS (NO) | 2006-09-20 | — | — | EP | claimed |
| WO-2005061483-A2 | MODULATORS OF PERIPHERAL 5-HT RECEPTORS | BIO-MEDISINSK INNOVASJON AS (NO) | 2005-07-07 | — | — | WO | claimed |
| US-5278158-A | Heteropolycyclic pyridyl or pyridyl oxide | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-01-11 | — | — | US | claimed |
| EP-0500319-A1 | Oxazinobenzazole compounds | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1992-08-26 | — | — | EP | claimed |
| CN-114790212-A | Oxazinoindole and oxazinoisoquinoline compounds and process for preparing same | 复旦大学 | 2022-07-26 | — | — | CN | disclosed |
| CN-114790212-A | Oxazinoindole and oxazinoisoquinoline compounds and process for preparing same | 复旦大学 | 2022-07-26 | — | — | CN | disclosed |
| US-20120094989-A1 | 5-HT RECEPTOR MODULATING COMPOUNDS | SERODUS AS (NO) | 2012-04-19 | — | — | US | disclosed |
| EP-2414331-A1 | 5-HT RECEPTOR MODULATING COMPOUNDS | Serodus AS (NO) | 2012-02-08 | — | — | EP | disclosed |
| CN-101463048-B | Ruthenium complex inducing DNA conformation transition and preparation thereof | UNIV SUN YAT SEN | 2011-06-22 | — | — | CN | disclosed |
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| US-4012511-A | ANTIULCER AGENTS | AYERST MCKENNA & HARRISON LTD. (CA) | 1977-03-15 | — | — | US | disclosed |
| US-4012511-A | ANTIULCER AGENTS | AYERST MCKENNA & HARRISON LTD. (CA) | 1977-03-15 | — | — | US | disclosed |
| US-3962236-A | ANTIDEPRESSANTS, ANTI-ULCER | AYERST MCKENNA AND HARRISON LTD. (CA) | 1976-06-08 | — | — | US | disclosed |
| US-3962236-A | ANTIDEPRESSANTS, ANTI-ULCER | AYERST MCKENNA AND HARRISON LTD. (CA) | 1976-06-08 | — | — | US | disclosed |
| US-3912729-A | Oxazinoindole- and thiazinoindole derivatives | AYERST MCKENNA & HARRISON | 1975-10-14 | — | — | US | disclosed |
| US-3910903-A | Oxazinoindole- and thiazinoindole derivatives | AYERST MCKENNA & HARRISON | 1975-10-07 | — | — | US | disclosed |
| US-3910901-A | Oxazinoindole- and thiazinoindole derivatives | AYERST MCKENNA & HARRISON | 1975-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254874-A1 | Modulators of Preripheral 5-Ht Receptors | HTR4, HTR5A, HTR6 | LMNA 2805/4885CCR1 1663/4885CCR5 411/4885 |
| US-20120094989-A1 | 5-HT RECEPTOR MODULATING COMPOUNDS | HTR5A, HTR1A, HTR2A | LMNA 730/4885CCR1 3570/4885CCR5 871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.