SCHEMBL5350528

SCHEMBL5350528

CC(C)C[C@H](NS(=O)(=O)c1ccccc1)C(=O)N[C@@H](C(C)C)[C@@H](O)c1c(-c2ccccc2)c1=O

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CTSS P25774 8/20 0.52
CTSK P43235 8/20 0.52
CTSL P07711 7/20 0.52
CTSB P07858 4/20 0.48
L3MBTL1 Q9Y468 1/20 0.44
MMP1 P03956 2/20 0.43
MMP2 P08253 2/20 0.43
MMP3 P08254 2/20 0.43
MMP7 P09237 2/20 0.43
MMP9 P14780 2/20 0.43
MMP13 P45452 2/20 0.43
LARS1 Q9P2J5 2/20 0.41
REN P00797 1/20 0.41
ADAMTS4 O75173 2/20 0.40
ADAM17 P78536 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5350533 1.00 CTSS (0.52) CTSSCTSKCTSLCTSBL3MBTL1
SCHEMBL14932686 1.00 CTSS (0.52) CTSSCTSKCTSLCTSBL3MBTL1
SCHEMBL5277957 1.00 CTSS (0.52) CTSSCTSKCTSLCTSBL3MBTL1
SCHEMBL7344740 0.80 CTSS (0.47) CTSSCTSKCTSLCTSBMMP1
SCHEMBL7337277 0.78 CTSK (0.59) CTSSCTSKCTSLCTSB
SCHEMBL31086879 0.75 CTSL (0.62) CTSSCTSKCTSLCTSBMMP1
SCHEMBL9054077 0.74 CTSS (0.60) CTSSCTSKCTSLCTSBL3MBTL1
SCHEMBL7370421 0.74 CTSK (0.45) CTSSCTSKCTSLREN
SCHEMBL9227916 0.74 CTSK (0.45) CTSSCTSKCTSLREN
SCHEMBL7343508 0.74 CTSK (0.45) CTSSCTSKCTSLREN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024153744-A1 AUTOPHAGY ACTIVATORS FOR THE TREATMENT OF RHABDOMYOLYSIS Institut National de la Santé et de la Recherche Médicale (FR) 2024-07-25 WO claimed
WO-2024018245-A1 USE OF CALPAIN INHIBITORS FOR THE TREATMENT OF THE DIABETIC KIDNEY DISEASE INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2024-01-25 WO claimed
US-20220370463-A1 STABILIZED C-FMS INTRACELLULAR FRAGMENTS (FICD) PROMOTE OSTEOCLAST DIFFERENTIATION AND ARTHRITIC BONE EROSION NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY 2022-11-24 US claimed
EP-3969913-A1 BIOMARKER FOR ASSESSMENT OF SPINAL CORD INJURY CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2022-03-23 EP claimed
US-20240279710-A1 FLUORESCENT PROBES TOHOKU TECHNO ARCH CO., LTD. (JP) 2024-08-22 US disclosed
WO-2024153744-A1 AUTOPHAGY ACTIVATORS FOR THE TREATMENT OF RHABDOMYOLYSIS Institut National de la Santé et de la Recherche Médicale (FR) 2024-07-25 WO disclosed
EP-4361166-A1 FLUORESCENT PROBES Tohoku Techno Arch Co., Ltd. (JP) 2024-05-01 EP disclosed
CN-117480175-A Fluorescent probe 东北泰克诺亚奇股份有限公司 2024-01-30 CN disclosed
WO-2024018245-A1 USE OF CALPAIN INHIBITORS FOR THE TREATMENT OF THE DIABETIC KIDNEY DISEASE INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2024-01-25 WO disclosed
WO-2022270607-A1 FLUORESCENT PROBES 株式会社 東北テクノアーチ 2022-12-29 WO disclosed
US-20220370463-A1 STABILIZED C-FMS INTRACELLULAR FRAGMENTS (FICD) PROMOTE OSTEOCLAST DIFFERENTIATION AND ARTHRITIC BONE EROSION NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY 2022-11-24 US disclosed
EP-4031160-A1 STABILIZED C-FMS INTRACELLULAR FRAGMENTS (FICD) PROMOTE OSTEOCLAST DIFFERENTIATION AND ARTHRITIC BONE EROSION New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery (US) 2022-07-27 EP disclosed
EP-3969913-A1 BIOMARKER FOR ASSESSMENT OF SPINAL CORD INJURY CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2022-03-23 EP disclosed
JP-2007246518-A CRYSTAL OF CYCLOPROPENONE COMPOUND MITSUBISHI PHARMA CORP 2007-09-27 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240279710-A1 FLUORESCENT PROBES CAPN1, CAPN2, CAPNS1 CTSS 146/4885CTSK 91/4885CTSL 145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.