Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352484 | 0.78 | RORC (0.46) | DRD2MEN1KMT2A | |
| SCHEMBL29532756 | 0.78 | RORC (0.46) | DRD2MEN1KMT2A | |
| SCHEMBL3384526 | 0.77 | DRD2 (0.45) | DRD2KDM4EDRD4DRD3S1PR2 | |
| SCHEMBL2531562 | 0.72 | DRD2 (0.41) | DRD2KDM4EDRD4DRD3S1PR2 | |
| SCHEMBL2430889 | 0.71 | RORC (0.48) | DRD2 | |
| SCHEMBL23215170 | 0.70 | SLC6A3 (0.47) | DRD2 | |
| SCHEMBL30722225 | 0.70 | GPR119 (0.44) | DRD2S1PR2 | |
| SCHEMBL19458929 | 0.70 | GPR119 (0.44) | DRD2S1PR2 | |
| SCHEMBL16838117 | 0.70 | SLC6A3 (0.46) | DRD2MEN1KMT2A | |
| SCHEMBL535063 | 0.68 | DRD2 (0.39) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |