Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557091 | 0.74 | CCR2 (0.33) | DRD2CCR2 | |
| SCHEMBL3384526 | 0.72 | DRD2 (0.45) | DRD2CCR1 | |
| SCHEMBL534534 | 0.71 | OPRD1 (0.36) | CCR2 | |
| SCHEMBL2531562 | 0.70 | DRD2 (0.41) | DRD2CCR2CCR1 | |
| SCHEMBL535062 | 0.68 | DRD2 (0.41) | DRD2 | |
| SCHEMBL2430891 | 0.67 | CCR2 (0.38) | DRD2CCR2 | |
| SCHEMBL3386011 | 0.67 | KCNN4 (0.39) | DRD2 | |
| SCHEMBL2534655 | 0.66 | CCR2 (0.40) | DRD2CCR2 | |
| SCHEMBL16422879 | 0.65 | DRD2 (0.45) | DRD2CCR1 | |
| SCHEMBL556468 | 0.65 | CCR2 (0.34) | DRD2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |