Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 9/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534472 | 0.88 | OPRD1 (0.37) | OPRD1OPRK1OPRM1CCR2RORC | |
| SCHEMBL557090 | 0.84 | RORC (0.39) | RORC | |
| SCHEMBL557091 | 0.75 | CCR2 (0.33) | CCR2RORCSLC6A3KMT2AMC4R | |
| SCHEMBL533858 | 0.73 | REN (0.46) | — | |
| SCHEMBL3384526 | 0.73 | DRD2 (0.45) | OPRD1OPRK1OPRM1KMT2A | |
| SCHEMBL556467 | 0.73 | RORC (0.40) | RORC | |
| SCHEMBL16423307 | 0.71 | RORC (0.42) | OPRD1OPRK1OPRM1RORCSLC6A3 | |
| SCHEMBL16423136 | 0.71 | SLC6A3 (0.41) | OPRD1OPRK1OPRM1SLC6A3KMT2A | |
| SCHEMBL535063 | 0.71 | DRD2 (0.39) | CCR2 | |
| SCHEMBL556661 | 0.71 | RORC (0.40) | OPRD1OPRK1OPRM1RORCSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |