Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAPDH | P04406 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30814757 | 1.00 | TAAR1 (0.52) | TAAR1HTR2AMPOTRPM8KMT2A | |
| Hydrochloric Acid SCHEMBL18524413 | 0.98 | TAAR1 (0.50) | TAAR1HTR2AMPOTRPM8KMT2A | |
| SCHEMBL32684199 | 0.83 | TAAR1 (0.52) | TAAR1HTR2AMPOTRPM8KMT2A | |
| SCHEMBL533937 | 0.83 | TAAR1 (0.52) | TAAR1HTR2AMPOTRPM8KMT2A | |
| SCHEMBL29556458 | 0.83 | MPO (0.44) | TAAR1HTR2AMPOTRPM8KMT2A | |
| SCHEMBL558725 | 0.83 | MPO (0.44) | TAAR1HTR2AMPOTRPM8KMT2A | |
| Hydrochloric Acid SCHEMBL27809219 | 0.82 | TAAR1 (0.50) | TAAR1HTR2AMPOTRPM8KMT2A | |
| Hydrochloric Acid SCHEMBL14157220 | 0.81 | MPO (0.43) | TAAR1HTR2AMPOTRPM8KMT2A | |
| SCHEMBL19602322 | 0.81 | DPP4 (0.35) | TAAR1HTR2AMPOTRPM8KMT2A | |
| SCHEMBL441642 | 0.80 | TAAR1 (0.54) | TAAR1HTR2AMPOTRPM8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109842-A1 | ACRYLAMIDE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-04-04 | — | — | US | disclosed |
| EP-4073038-A1 | ACRYLAMIDE COMPOUNDS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2022-10-19 | — | — | EP | disclosed |
| CN-114667280-A | Acrylamide compound | 大塚制药株式会社 | 2022-06-24 | — | — | CN | disclosed |
| WO-2021117733-A1 | ACRYLAMIDE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-06-17 | — | — | WO | disclosed |
| US-9255090-B2 | Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-02-09 | — | — | US | disclosed |
| US-20150252036-A1 | Heterocyclyl Derivatives and their use as Prostaglandin D2 Receptor Modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2015-09-10 | — | — | US | disclosed |
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2009117097-A1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252036-A1 | Heterocyclyl Derivatives and their use as Prostaglandin D2 Receptor Modulators | PTGDR, PTGER1, PTGDR2 | TAAR1 401/4885HTR2A 265/4885MPO 2462/4885 |
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | TAAR1 1781/4885HTR2A 3006/4885MPO 829/4885 |
| US-20240109842-A1 | ACRYLAMIDE COMPOUNDS | HPGDS, MYADM, ACR | TAAR1 1656/4885HTR2A 750/4885MPO 538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.