Urea

Urea

SCHEMBL5353728

NC(N)=O.Nc1nc(N)nc(N)n1.O.O.[C]N

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ADORA2A known ✓ P29274 1/20 0.31
ADORA1 known ✓ P30542 1/20 0.31
CYP1A2 P05177 1/20 0.44
LMNA P02545 2/20 0.38
ALDH1A1 P00352 1/20 0.38
OR51E2 Q9H255 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
PDPK1 O15530 1/20 0.37
CASP1 P29466 1/20 0.33
HSP90AB1 P08238 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urea SCHEMBL10914180 0.90 CYP1A2 (0.50) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL51851 0.90 CYP1A2 (0.50) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL15483993 0.90 CYP1A2 (0.50) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL28050095 0.87 CYP1A2 (0.48) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL28466157 0.87 CYP1A2 (0.48) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL4899185 0.84 CYP1A2 (0.46) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL574673 0.84 CYP1A2 (0.46) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL11663512 0.84 CYP1A2 (0.46) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL6052731 0.84 CYP1A2 (0.46) CYP1A2LMNAALDH1A1OR51E2TDP1
Urea SCHEMBL6471684 0.84 CYP1A2 (0.46) CYP1A2LMNAALDH1A1OR51E2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4091707-B1 APPARATUS FOR THE PRODUCTION OF MELAMINE PROMAN AG (CH) 2024-07-03 EP disclosed
CN-110734406-B Low energy consumption process with reduced ammonia consumption for the production of high purity melamine by urea pyrolysis and related plant 普罗曼有限公司 2024-04-30 CN disclosed
CN-116789615-A Improved process for the production of high-purity melamine from urea pyrolysis with reduced energy consumption and improved integration with urea plants 欧洲技术三聚氰氨股份公司 2023-09-22 CN disclosed
EP-4245755-A1 PROCESS FOR THE PRODUCTION OF HIGH-PURITY MELAMINE FROM UREA PYROLYSIS, WITH REDUCED ENERGY CONSUMPTION AND IMPROVED INTEGRATION WITH THE UREA PLANT EUROTECNICA MELAMINE AG (CH) 2023-09-20 EP disclosed
CN-115382353-A Device and method for treating a gas flow leaving the reaction section of a melamine production plant 欧洲技术三聚氰氨股份公司 2022-11-25 CN disclosed
EP-4091708-A1 APPARATUS FOR THE TREATMENT OF GASEOUS STREAMS LEAVING THE REACTION SECTION IN A PLANT FOR THE PRODUCTION OF MELAMINE AND CORRESPONDING PROCESS EUROTECNICA MELAMINE AG (CH) 2022-11-23 EP disclosed
CN-115364805-A Plant for the production of melamine 欧洲技术三聚氰氨股份公司 2022-11-22 CN disclosed
EP-3597641-B1 LOW-ENERGY CONSUMPTION PROCESS WITH REDUCED AMMONIA CONSUMPTION, FOR THE PRODUCTION OF HIGH-PURITY MELAMINE THROUGH THE PYROLYSIS OF UREA, AND RELATIVE PLANT EUROTECNICA MELAMINE AG (CH) 2021-03-10 EP disclosed
US-10829459-B2 Low-energy consumption process with reduced ammonia consumption, for the production of high-purity melamine through the pyrolysis of urea, and relative plant EUROTECNICA MELAMINE, LUXEMBURG, ZWEIGNIEDERLASSUNG IN ITTIGEN (CH) 2020-11-10 US disclosed
CN-110734406-A Low energy method with reduced ammonia consumption for the production of high purity melamine by urea pyrolysis and related plant 欧洲技术设于伊特根的三聚氰氨卢森堡分支机构 2020-01-31 CN disclosed
WO-2007119156-A2 IMPROVED PROCESS FOR THE PRODUCTION OF MELAMINE WITH AN INCREASED YIELD EUROTECNICA MELAMINE, LUXEMBURG, ZWEIGNIEDERLASSUNG IN ITTIGEN (CH) 2007-10-25 WO disclosed
CN-1276915-C Improved process for the high-yield production of high-purity melamine EUROTECNICA GROUP S A SWITZERL (CH) 2006-09-27 CN disclosed
CN-1260217-C Method for obtaining crystalline melamine from a melamine melt DSM IP ASSETS BV (NL) 2006-06-21 CN disclosed
CN-1553902-A Process for obtaining crystalline melamine from melamine melt DSM IP财产有限公司 2004-12-08 CN disclosed
CN-1538961-A Improved process for the high-yield production of high-purity melamine ŷ�޼����������޹�˾(��ʿ�ֹ�˾) 2004-10-20 CN disclosed
EP-1425271-A1 PROCESS FOR OBTAINING CRYSTALLINE MELAMINE FROM MELAMINE MELT DSM IP Assets B.V. (NL) 2004-06-09 EP disclosed
EP-1404658-A1 IMPROVED PROCEDURE FOR THE PRODUCTION OF HIGH-PURITY MELAMINE WITH HIGH YIELDS Eurotecnica Group S.A. (CH) 2004-04-07 EP disclosed
WO-2003022823-A1 PROCESS FOR OBTAINING CRYSTALLINE MELAMINE FROM MELAMINE MELT DSM IP ASSETS B.V. (NL) 2003-03-20 WO disclosed
WO-2002100839-A1 IMPROVED PROCEDURE FOR THE PRODUCTION OF HIGH-PURITY MELAMINE WITH HIGH YIELDS EUROTECNICA GROUP S.A. (SWISS BRANCH) (CH) 2002-12-19 WO disclosed