SCHEMBL535420

SCHEMBL535420

C[CH]Oc1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.42
CYP2A6 P11509 1/20 0.42
MAOB P27338 3/20 0.41
MAOA P21397 2/20 0.41
HPGD P15428 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C19 P33261 1/20 0.38
PPARA Q07869 1/20 0.38
MMP13 P45452 1/20 0.35
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9065756 0.80 LMNA (0.38) LMNACYP2A6MAOBMAOAHPGD
SCHEMBL9065752 0.80 LMNA (0.38) LMNACYP2A6MAOBMAOAHPGD
SCHEMBL8736431 0.77
SCHEMBL354673 0.76 CA1 (0.61) LMNACYP2A6CA1CA2CA9
SCHEMBL535498 0.76 ACHE (0.50) LMNACYP2A6MEN1KMT2ACA1
SCHEMBL96633 0.74 HSD17B10 (0.46) LMNACYP2A6MAOBMAOAHPGD
SCHEMBL1547675 0.74 TSHR (0.42) CYP3A4MAPTCYP2C19AHR
SCHEMBL2126713 0.74 MEN1 (0.50) LMNAHPGDMEN1KMT2ACA1
SCHEMBL1224845 0.74 CYP2A6 (0.42) LMNACYP2A6MAOBMAOAMEN1
SCHEMBL194685 0.74 LMNA (0.42) LMNACYP2A6MAOBMAOAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 290 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11958923-B2 Compositions with high refractive index and abbe number Johnson & Johnson Surgical Vision, Inc. (US) 2024-04-16 US claimed
US-20230279169-A1 HIGH REFRACTIVE INDEX, HIGH ABBE COMPOSITIONS Johnson & Johnson Surgical Vision, Inc. 2023-09-07 US claimed
US-20230265230-A1 COMPOSITIONS WITH HIGH REFRACTIVE INDEX AND ABBE NUMBER Johnson & Johnson Surgical Vision, Inc. 2023-08-24 US claimed
US-11667742-B2 Compositions with high refractive index and Abbe number Johnson & Johnson Surgical Vision, Inc. (US) 2023-06-06 US claimed
CN-112292100-A Composition with high reaction index and high dispersion coefficient 强生外科视力公司 2021-01-29 CN claimed
WO-2020225686-A1 HIGH REACTIVE INDEX, HIGH ABBE COMPOSITIONS Johnson & Johnson Surgical Vision, Inc. (US) 2020-11-12 WO claimed
US-20200347167-A1 COMPOSITIONS WITH HIGH REFRACTIVE INDEX AND ABBE NUMBER Johnson & Johnson Surgical Vision, Inc. 2020-11-05 US claimed
EP-3362461-A1 MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE Modernatx, Inc. (US) 2018-08-22 EP claimed
EP-3362460-A1 MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING Modernatx, Inc. (US) 2018-08-22 EP claimed
WO-2017066782-A1 HYDROPHOBIC MRNA CAP ANALOGS MODERNATX, INC. (US) 2017-04-20 WO claimed
EP-0807114-A1 BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1997-11-19 EP claimed
WO-1996023791-A1 BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1996-08-08 WO claimed
US-4960768-A Acyloxythiophene-carboxamide fungicides BAYER AKTIENGESELLSCHAFT (DE) 1990-10-02 US claimed
US-4863954-A Acyloxythiophene-carboxamide fungicides BAYER AKTIENGESELLSCHAFT (DE) 1989-09-05 US claimed
EP-0159584-B1 N-(AZOLYLCARBAMOYL)-HYDROXYL AMINES AND FUNGICIDES CONTAINING THEM BASF Aktiengesellschaft (DE) 1989-01-18 EP claimed
EP-0241735-A2 Acyloxythiophene carbon amide BAYER AG (DE) 1987-10-21 EP claimed
US-4678798-A PLANTS, SEEDS BASF AKTIENGESELLSCHAFT (DE) 1987-07-07 US claimed
EP-0159584-A2 N-(azolylcarbamoyl)-hydroxyl amines and fungicides containing them BASF Aktiengesellschaft (DE) 1985-10-30 EP claimed
US-4430345-A 6-ALDOXIME OR KETOXIME BICYCLO(2,2,1)-NEPTANES FOR TREATMENT OF THROMBOSIS NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1984-02-07 US claimed
EP-0013607-B1 SUBSTITUTED BICYCLO (2,2,1)HEPTANES AND BICYCLO (2,2,1) HEPT-2-ENES AND THEIR PHARMACEUTICAL COMPOSITIONS NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1983-03-23 EP claimed