Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 8/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358234 | 0.91 | LMNA (0.48) | LMNAHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL5362014 | 0.82 | ALDH1A1 (0.48) | LMNAHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL5362222 | 0.77 | HCAR3 (0.49) | LMNAHPGDALDH1A1 | |
| SCHEMBL15774565 | 0.76 | HPGD (0.62) | LMNAHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL5364346 | 0.74 | TP53 (0.52) | LMNAHPGDKMT2AMEN1POLB | |
| SCHEMBL5352150 | 0.72 | ALDH1A1 (0.55) | HPGDCYP1A2CYP2C9MAPK1CYP2C19 | |
| SCHEMBL15992013 | 0.71 | PPARG (0.60) | LMNAHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL22382554 | 0.69 | HPGD (0.55) | LMNAHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL1377663 | 0.68 | HPGD (0.69) | LMNAHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL1378843 | 0.68 | HPGD (0.72) | LMNAHPGDCYP1A2CYP2C9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |