Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358234 | 0.91 | LMNA (0.48) | LMNAHPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL5355346 | 0.82 | LMNA (0.55) | ALDH1A1LMNAHPGDCYP1A2CYP2C9 | |
| SCHEMBL5364346 | 0.80 | TP53 (0.52) | ALDH1A1NAMPTLMNAHPGDKMT2A | |
| SCHEMBL5352150 | 0.77 | ALDH1A1 (0.55) | ALDH1A1HPGDCYP1A2CYP2C9MAPK1 | |
| SCHEMBL5358019 | 0.75 | FGFR1 (0.49) | ALDH1A1L3MBTL1LMNAHPGDMAPK1 | |
| SCHEMBL31744961 | 0.74 | FGFR1 (0.40) | ALDH1A1NAMPTLMNAHPGDMAPK1 | |
| SCHEMBL5356306 | 0.73 | KMT2A (0.54) | ALDH1A1TSHRHPGDCYP1A2CYP2C9 | |
| SCHEMBL13681674 | 0.69 | HTT (0.74) | L3MBTL1NAMPTLMNAMAPK1KMT2A | |
| SCHEMBL5426958 | 0.68 | GSK3B (0.64) | ALDH1A1TSHRL3MBTL1NAMPTKMT2A | |
| SCHEMBL13450223 | 0.67 | EPHX2 (0.59) | ALDH1A1TSHRL3MBTL1PAX8NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |