Sugi Predict

Sugi Predict / Compounds / SCHEMBL5355565

SCHEMBL5355565

SCHEMBL5355565

CCCC(n1c(C)nc2c(Oc3ccccc3)nc3c(c21)CCCC3)S(=O)(=O)C(C)C

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ BCHE P06276 2/20 0.31
▸ ACHE P22303 2/20 0.31
▸ HSD17B10 Q99714 2/20 0.31
▸ ADORA3 P0DMS8 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.30
▸ MEN1 O00255 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ HTT P42858 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ NPSR1 Q6W5P4 1/20 0.30
▸ TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5406203 0.89 HSD17B10 (0.32) POLBL3MBTL1BCHEACHEHSD17B10
SCHEMBL6477156 0.86 HTT (0.33) POLBBCHEHTT
SCHEMBL5348192 0.83 ADORA3 (0.33) POLBL3MBTL1BCHEACHEADORA3
SCHEMBL5355562 0.76 BCHE (0.32) POLBBCHEACHEHTT
SCHEMBL6486089 0.74 BCHE (0.33) POLBL3MBTL1BCHEACHEHSD17B10
SCHEMBL6483879 0.73 ACHE (0.33) POLBL3MBTL1BCHEACHEKDM4E
SCHEMBL5406199 0.70 BCHE (0.32) POLBBCHEACHEHSD17B10ALDH1A1
SCHEMBL5368947 0.69 BCHE (0.36) BCHEACHEALDH1A1HTT
SCHEMBL5366471 0.68 HTT (0.35) POLBBCHEACHEHTT
SCHEMBL16681004 0.66 MEN1 (0.32) KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7276515-B2 Thioether substituted imidazoquinolines COLEY PHARMACEUTICAL GROUP, INC. (US) 2007-10-02 — — US disclosed
US-6949649-B2 Thioether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES CO. (US) 2005-09-27 — — US disclosed
US-20050209268-A1 Thioether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2005-09-22 — — US disclosed
EP-1451191-A1 THIOETHER SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2004-09-01 — — EP disclosed
US-20040097736-A1 Thioether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2004-05-20 — — US disclosed
US-6667312-B2 Useful as immune response modifiers 3M INNOVATIVE PROPERTIES COMPANY 2003-12-23 — — US disclosed
WO-2003050121-A1 THIOETHER SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2003-06-19 — — WO disclosed
US-20030100764-A1 Thioether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2003-05-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050209268-A1 Thioether substituted imidazoquinolines IFNG, IRF3, IL2 POLB 3882/4885L3MBTL1 1317/4885BCHE 4028/4885
US-20040097736-A1 Thioether substituted imidazoquinolines IFNG, IRF3, IL2 POLB 3882/4885L3MBTL1 1317/4885BCHE 4028/4885
US-20030100764-A1 Thioether substituted imidazoquinolines IFNG, IRF3, IL2 POLB 3882/4885L3MBTL1 1317/4885BCHE 4028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.