Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | CASR | P41180 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 9/20 | 0.49 |
| ▸ | CNR2 | P34972 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13066398 | 0.80 | KMT2A (0.56) | EPHX2CNR1ALDH1A1HPGD | |
| SCHEMBL13066966 | 0.80 | SMN1; SMN2 (0.68) | MTNR1AMTNR1BEPHX2CNR1CNR2 | |
| SCHEMBL5350801 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1BCASREPHX2CNR1 | |
| SCHEMBL5351192 | 0.72 | AOC3 (0.50) | — | |
| SCHEMBL8248986 | 0.71 | CNR1 (0.72) | MTNR1AMTNR1BCASREPHX2CNR1 | |
| SCHEMBL11301023 | 0.71 | CYP2C9 (0.36) | ALDH1A1 | |
| SCHEMBL11400550 | 0.71 | CYP2C9 (0.36) | ALDH1A1 | |
| SCHEMBL4219824 | 0.71 | MTNR1A (1.00) | MTNR1AMTNR1BCASREPHX2CNR1 | |
| SCHEMBL2726416 | 0.70 | MTNR1A (0.72) | MTNR1AMTNR1BCASREPHX2CNR1 | |
| SCHEMBL3800928 | 0.69 | ITGA4 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202253-B2 | Cycloalkyl inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202253-B2 | Cycloalkyl inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202253-B2 | Cycloalkyl inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-10 | — | — | US | disclosed |