Pyrazole

Pyrazole

SCHEMBL5357653

O.c1cn[nH]c1.c1cn[nH]c1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Pyrazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrazole SCHEMBL30368523 1.00
Pyrazole SCHEMBL4708002 1.00
Pyrazole SCHEMBL6022174 0.97
Benzene SCHEMBL27335689 0.97
Pyrazole SCHEMBL28037467 0.97
Pyrazole SCHEMBL30854861 0.96
Pyrazole SCHEMBL30626480 0.96
Pyrazole SCHEMBL7671561 0.96
Pyrazole SCHEMBL5664483 0.96
Pyrazole SCHEMBL1384 0.96

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119874621-A Pharmaceutical composition containing pyrazole ether compound and application thereof 上海晓明检测技术服务有限公司 2025-04-25 CN claimed
CN-114516839-B Pyrazole ether compound as well as preparation method and application thereof 湖南海利常德农药化工有限公司 2024-08-27 CN claimed
CN-118324741-A Pyrazole ether compound as well as preparation method and application thereof 南通泰禾化工股份有限公司 2024-07-12 CN claimed
CN-116003322-B Pyrazole ether compound as well as preparation method and application thereof 南通泰禾化工股份有限公司 2024-05-31 CN claimed
CN-116003322-A Pyrazole ether compound as well as preparation method and application thereof 南通泰禾化工股份有限公司 2023-04-25 CN claimed
WO-2023284761-A1 PYRAZOLE ETHER COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 南通泰禾化工股份有限公司 2023-01-19 WO claimed
CN-114516839-A Pyrazole ether compound and preparation method and application thereof 湖南海利常德农药化工有限公司 2022-05-20 CN claimed
CN-212017590-U Pyrazolyl ether bacterium Ming Mian oil preparing device 贵州蓝太生物科技有限公司 2020-11-27 CN claimed
CN-105037342-B Pyrazole ether compounds with activity of weeding and its application 华中农业大学 2018-10-09 CN claimed
CN-105037342-A Pyrazole ether compound with herbicidal activity and application thereof UNIV HUAZHONG AGRICULTURAL 2015-11-11 CN claimed
US-20040122011-A1 Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy PHARMACIA CORPORATION 2004-06-24 US claimed
US-4316040-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US claimed
US-4298749-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1981-11-03 US claimed
EP-0007990-B1 PYRAZOLE ETHER DERIVATIVES, PROCESS FOR THEIR PREPARATION AND HERBICIDES CONTAINING THEM BASF Aktiengesellschaft (DE) 1981-03-25 EP claimed
JP-55009062-A None JP disclosed
EP-4653423-A1 PYRAZOL-5-ETHER COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF CAC Nantong Chemical Co., Ltd. (CN) 2025-11-26 EP disclosed
CN-120943782-A Preparation method of pyrazole ether compound 南通泰禾化工股份有限公司 2025-11-14 CN disclosed
EP-0007990-B1 PYRAZOLE ETHER DERIVATIVES, PROCESS FOR THEIR PREPARATION AND HERBICIDES CONTAINING THEM BASF Aktiengesellschaft (DE) 1981-03-25 EP disclosed
EP-0007990-A1 Pyrazole ether derivatives, process for their preparation and herbicides containing them BASF Aktiengesellschaft (DE) 1980-02-20 EP disclosed
JP-S559062-A PYRAZOLE ETHER DERIVATIVES AND HERBICIDE CONTAINING THEIR COMPOUNDS BASF AG (DE) 1980-01-22 JP disclosed