Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31300000 | 0.81 | ALDH1A1 (0.37) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL2293604 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL2396390 | 0.65 | ALDH1A1 (0.88) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL28167196 | 0.65 | ALDH1A1 (0.88) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL30359537 | 0.65 | ALDH1A1 (0.88) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL3417188 | 0.65 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL240402 | 0.65 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL10896997 | 0.65 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL1331942 | 0.65 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL842 | 0.65 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 480 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12435175-B2 | Melamine-formaldehyde foam with improved weather resistance | BASF SE (DE) | 2025-10-07 | — | — | US | claimed |
| WO-2025202160-A1 | CLEANING COMPOSITIONS COMPRISING UV LIGHT STABILIZERS | BASF SE (DE) | 2025-10-02 | — | — | WO | claimed |
| WO-2025149495-A1 | A HIGH SPF GEL COMPOSITION COMPRISING NIACINAMIDE | UNILEVER IP HOLDINGS B.V. (NL) | 2025-07-17 | — | — | WO | claimed |
| EP-4543409-A1 | STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME | L'OREAL (FR) | 2025-04-30 | — | — | EP | claimed |
| US-12257332-B2 | Prevention of the oxidation of perfumery raw materials | FIRMENICH SA (CH) | 2025-03-25 | — | — | US | claimed |
| WO-2024256011-A1 | STABILIZER OR STABILIZER COMPOSITION FOR STABILIZING DIHYDROAVENANTHRAMIDE D | SYMRISE AG (DE) | 2024-12-19 | — | — | WO | claimed |
| CN-119033623-A | Guaiac azulene liposome and preparation method and application thereof | 江门职业技术学院 | 2024-11-29 | — | — | CN | claimed |
| CN-118986777-A | Nanometer liposome protective agent with ultraviolet resistance and oxidation resistance functions, preparation method, preparation and application thereof | 江门职业技术学院 | 2024-11-22 | — | — | CN | claimed |
| EP-4452206-A1 | COSMETIC COMPOSITION COMPRISING INDIRUBIN AND A MIXTURE OF ANTIOXIDANTS | Laboratoires Clarins (FR) | 2024-10-30 | — | — | EP | claimed |
| CN-118319820-B | Composition with whitening and skin brightening effects and preparation method thereof | 广州旭妆生物科技有限公司 | 2024-08-30 | — | — | CN | claimed |
| EP-1994921-A1 | Fragrance composition comprising the combination of one filter A hydroxyaminobenzophenone, one filter B cinnamate and of one compound C piperidinole, benzotriazole or dibenzoylmethane | L'Oreal (FR) | 2008-11-26 | — | — | EP | claimed |
| US-7431917-B2 | Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | L'OREAL (FR) | 2008-10-07 | — | — | US | claimed |
| US-7357920-B2 | Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | L'OREAL (FR) | 2008-04-15 | — | — | US | claimed |
| US-7357919-B2 | Photostable photoprotective compositions comprising dibenzoylmethane and arylalkyl benzoate compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | L'OREAL (FR) | 2008-04-15 | — | — | US | claimed |
| US-20060104924-A1 | Photostable photoprotective compositions comprising dibenzoylmethane and arylalkyl benzoate compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | L'OREAL (FR) | 2006-05-18 | — | — | US | claimed |
| EP-1649900-A2 | Light screening composition comprising a derivative of dibenzoylmethane, a bis-resorcinyl triazine and a compound capable of accepting energy of the excited triplet state of dibenzoylmethane; process for photostabilisation | L'OREAL (FR) | 2006-04-26 | — | — | EP | claimed |
| EP-1649902-A2 | Light screening composition comprising a dibenzoylmethane derivative, an arylalkyl benzoat derivative and a compound capable of accepting energie from the excited triplet state of dibenzoylmethane; process of photostabilisation | L'OREAL (FR) | 2006-04-26 | — | — | EP | claimed |
| EP-1649901-A2 | Light screening composition comprising a dibenzoylmethane derivative, a lipophilic amide and a compound capable of accepting energy from the excited triplet state of dibenzoylmethane; process for photostabilsation | L'OREAL (FR) | 2006-04-26 | — | — | EP | claimed |
| US-20060083698-A1 | Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | L'OREAL (FR) | 2006-04-20 | — | — | US | claimed |
| US-20060083699-A1 | Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | L'OREAL (FR) | 2006-04-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060083699-A1 | Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | DHPS, DDT, CUTA | ALDH1A1 459/4885KDM4E 342/4885LMNA 3944/4885 |
| US-20060083698-A1 | Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | NOTUM, CUTA, WEE1 | ALDH1A1 753/4885KDM4E 1797/4885LMNA 4109/4885 |
| US-20060104924-A1 | Photostable photoprotective compositions comprising dibenzoylmethane and arylalkyl benzoate compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) | DDT, TYR, CUTA | ALDH1A1 290/4885KDM4E 1271/4885LMNA 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.