SCHEMBL5361006

SCHEMBL5361006

CC(C)C1=Cc2c(Cl)cccc2C1

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.33
ADRA2A P08913 2/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
ADRA1D P25100 1/20 0.33
ADRA1A P35348 1/20 0.33
ADRA1B P35368 1/20 0.33
AHR P35869 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
PNMT P11086 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
NFKB1 P19838 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
GLA P06280 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6909731 0.85 EIF2AK1 (0.32)
SCHEMBL6909850 0.83
SCHEMBL5954049 0.79 GABRA1 (0.39) CYP1A2CYP3A4LMNA
SCHEMBL6648035 0.78
SCHEMBL6647941 0.78
SCHEMBL1453793 0.76 ADRA2A (0.37) CYP2D6ADRA2AADRA2BADRA2CADRA1D
SCHEMBL4467574 0.74 PRCP (0.35) ADRA2AADRA2BADRA2C
SCHEMBL6052968 0.73 HTR7 (0.34) CYP2D6ADRA2AADRA2BADRA2CCYP1A2
SCHEMBL16393570 0.71 AHR (0.36) CYP2D6ADRA2AADRA2BADRA2CADRA1D
SCHEMBL5953900 0.70 ADRA2A (0.40) CYP2D6ADRA2AADRA2BADRA2CADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1421090-B1 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM EXXONMOBIL CHEM PATENTS INC (US) 2014-03-26 EP disclosed
US-7297747-B2 Polymerization process and polymer composition EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-11-20 US disclosed
CN-1332966-C Bridged bis (indenyl) metallocene compounds EXXONMOBIL CHEM PATENTS INC (US) 2007-08-22 CN disclosed
US-7122498-B2 Metallocenes and catalyst compositions derived therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-10-17 US disclosed
CN-1274701-C Metallocenes containing bridged 4-phenyl-indenyl ligands for the polymerization of olefins EXXONMOBIL CHEM PATENTS INC (US) 2006-09-13 CN disclosed
EP-1481997-B1 Propylene impact copolymers EXXONMOBIL CHEM PATENTS INC (US) 2006-08-16 EP disclosed
US-20060052620-A1 Preparation of substituted indenes BASELL POLYOLEFINE GMBH (DE) 2006-03-09 US disclosed
EP-1632506-A1 Propylene polymer ExxonMobil Chemical Patents Inc. (US) 2006-03-08 EP disclosed
EP-1411058-B1 Bridged bisindenyl metallocene compositions EXXONMOBIL CHEM PATENTS INC (US) 2005-11-09 EP disclosed
EP-1313746-B1 METALLOCENES WITH A BRIDGED 4-PHENYL-INDENYL-LIGAND FOR OLEFIN POLYMERISATION EXXONMOBIL CHEM PATENTS INC (US) 2005-07-27 EP disclosed
US-6376410-B1 COORDINATION POLYMERIZATION CATALYST ON SUPPORT EXXONMOBIL CHEMICAL PATENTS INC. 2002-04-23 US disclosed
US-6376627-B1 COORDINATION CATALYSTS EXXONMOBIL CHEMICAL PATENTS INC. 2002-04-23 US disclosed
US-6376407-B1 COORDINATION POLYMERIZATION CATALYST EXXONMOBIL CHEMICAL PATENTS INC. 2002-04-23 US disclosed
US-6376408-B1 COORDINATION POLYMERIZATION CATALYST ON SUPPORT EXXONMOBIL CHEMICAL PATENTS INC. 2002-04-23 US disclosed
US-6376409-B1 COORDINATION POLYMERIZATION CATALYST ON SUPPORT EXXONMOBIL CHEMICAL PATENTS INC. 2002-04-23 US disclosed
US-6376412-B1 COORDINATION POLYMERIZATION CATALYST ON SUPPORT EXXONMOBIL CHEMICAL PATENTS INC. 2002-04-23 US disclosed
US-6342566-B2 CHEMICAL REACTOR; USING COORDINATION CATALYST EXXONMOBIL CHEMICAL PATENTS INC. 2002-01-29 US disclosed
WO-2002002575-A1 METALLOCENES WITH A BRIDGED 4-PHENYL-INDENYL-LIGAND FOR OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS, INC. (US) 2002-01-10 WO disclosed
US-20010034411-A1 Propylene impact copolymers EXXONMOBIL CHEMICAL PATENTS INC. 2001-10-25 US disclosed
WO-2001058970-A1 PROPYLENE IMPACT COPOLYMERS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2001-08-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060052620-A1 Preparation of substituted indenes INTS9, CYP1A2, INF2 CYP2D6 44/4885ADRA2A 2316/4885ADRA2B 2650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.