Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Quinolinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | AGER | Q15109 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinolinic Acid SCHEMBL29358561 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL28576614 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL11408572 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL11408577 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL15401426 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL1897907 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL5674127 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL5381550 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL3425488 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 | |
| Quinolinic Acid SCHEMBL8076149 | 0.96 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114107111-B | Fermentation method of clostridium butyricum, microecological preparation and application thereof | 江苏傲农生物科技有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-116669555-A | Spore composition, its production and use | 巴斯夫欧洲公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-114107111-A | Fermentation method of clostridium butyricum, microecological preparation and application thereof | 南昌傲农生物科技有限公司 | 2022-03-01 | — | — | CN | disclosed |
| US-7211377-B1 | Method for detecting the presence of dormant cryptobiotic microorganisms | MICROBIOSYSTEMS, LIMITED PARTNERSHIP (US) | 2007-05-01 | — | — | US | disclosed |
| JP-2005287494-A | METHOD FOR DETECTING DORMANT CRYPTOBIOTIC MICROBE | MICROBIOSYSTEMS LP | 2005-10-20 | — | — | JP | disclosed |
| EP-1582859-A1 | Method for detecting the presence of dormant cryptobiotic microorganisms | MicroBioSystems Limited Partnership (US) | 2005-10-05 | — | — | EP | disclosed |
| CN-1677089-A | Method for detecting the presence of dormant cryptobiotic microorganisms | MICROBIOSYSTEMS LTD PARTNERSHI (US) | 2005-10-05 | — | — | CN | disclosed |