Quinolinic Acid

Quinolinic Acid

SCHEMBL3425488

O=C([O-])c1cccnc1C(=O)[O-].[Na+].[Na+]

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Quinolinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 1/20 0.37
CA4 known ✓ P22748 1/20 0.37
KDM4E B2RXH2 7/20 0.53
ALDH1A1 P00352 4/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
MAPT P10636 2/20 0.53
CYP3A4 P08684 1/20 0.53
ALOX15 P16050 1/20 0.53
TSHR P16473 1/20 0.53
BLM P54132 1/20 0.53
AGER Q15109 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
HPGD P15428 1/20 0.47
TDP1 Q9NUW8 1/20 0.45
NAPRT Q6XQN6 2/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CYP1A2 P05177 1/20 0.39
PARP1 P09874 1/20 0.39
P2RX7 Q99572 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinolinic Acid SCHEMBL29358561 1.00 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL11408572 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL1897907 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL28576614 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL11408577 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL5674127 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL5381550 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL15401426 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL5361017 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4
Quinolinic Acid SCHEMBL8076149 0.96 KDM4E (0.53) KDM4EALDH1A1L3MBTL1MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-214735481-U 2, 3-pyridinedicarboxylic acid continuous production device 江西鑫海高分子材料有限公司 2021-11-16 CN claimed
CN-110590655-A Method for continuously producing 2, 3-dipicolinic acid by oxidizing sodium chlorate 山西竣铭科技有限公司 2019-12-20 CN claimed
CN-106187877-B A kind of production method of quinolinic acid 湖北金玉兰医药科技有限公司 2018-11-23 CN claimed
CN-106187877-A A kind of production method of quinolinic acid 湖北金玉兰医药科技有限公司 2016-12-07 CN claimed
CN-102399182-A Process for producing quinolinic acid ANGANG STEEL CO LTD 2012-04-04 CN claimed
CN-1234736-C Method for preparation of zinc or copper containing acrylic acid resin OCEAN UNIV CHINA (CN) 2006-01-04 CN claimed
CN-1544488-A Method for preparation of zinc or copper containing acrylic acid resin 中国海洋大学 2004-11-10 CN claimed
EP-0490417-A1 Bleach-builder precursors UNILEVER N.V. (NL) 1992-06-17 EP claimed
US-5069812-A DERIVATIVES OF 2,6-DICARBOXY-4-OXY-PYRIDINES LEVER BROTHERS COMPANY (US) 1991-12-03 US claimed
US-20240018376-A1 AQUEOUS ADDITIVE SOLUTION FOR INK COMPOSITION, AQUEOUS COLORANT SOLUTION FOR INK COMPOSITION, INK COMPOSITION, INK COMPOSITION FOR INK JET RECORDING, AND INK JET RECORDING METHOD FUJIFILM CORPORATION (JP) 2024-01-18 US disclosed
US-11845873-B2 Dye ink composition, dye ink for ink jet recording, and ink jet recording method FUJIFILM CORPORATION (JP) 2023-12-19 US disclosed
CN-114364755-B Dye ink composition, cyan dye ink, dye ink for inkjet recording, inkjet recording method, and dye aqueous solution 富士胶片株式会社 2023-02-10 CN disclosed
US-20230039668-A1 DYE INK COMPOSITION, CYAN DYE INK, DYE INK FOR INK JET RECORDING, INK JET RECORDING METHOD, AND AQUEOUS DYE SOLUTION FUJIFILM CORPORATION (JP) 2023-02-09 US disclosed
EP-4019255-A1 DYE INK COMPOSITION, CYAN DYE INK, DYE INK FOR INKJET PRINTING, INKJET PRINTING METHOD, AND DYE AQUEOUS SOLUTION FUJIFILM Corporation (JP) 2022-06-29 EP disclosed
US-6251576-B1 AN AROMATIC SULFONAMIDE COMPOUND CONTAINING A HYDROXYL GROUP FUJI PHOTO FILM CO., LTD. (JP) 2001-06-26 US disclosed
US-6074810-A COUPLERS FOR LAYERS OF SILVER HALIDE EMULSIONS FUJI PHOTO FILM CO., LTD. (JP) 2000-06-13 US disclosed
EP-0930528-A1 Silver halide photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1999-07-21 EP disclosed
US-5780210-A Color developing agent, silver halide photographic light-sensitive material and image forming method FUJI PHOTO FILM CO., LTD. (JP) 1998-07-14 US disclosed
EP-0727708-A1 Color developing agent, silver halide photographic light-sensitive material and image forming method FUJI PHOTO FILM CO., LTD. (JP) 1996-08-21 EP disclosed
US-5069812-A DERIVATIVES OF 2,6-DICARBOXY-4-OXY-PYRIDINES LEVER BROTHERS COMPANY (US) 1991-12-03 US disclosed