Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 13/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506154 | 0.91 | DHODH (0.67) | DHODHKDM4ERAB9AHDAC6 | |
| SCHEMBL505582 | 0.87 | DHODH (0.64) | DHODHKDM4EPARP1ALDH1A1HPGD | |
| SCHEMBL536119 | 0.85 | DHODH (0.70) | DHODHHDAC6 | |
| SCHEMBL6840235 | 0.84 | TNKS (0.54) | DHODHKDM4ERAB9APARP1ALDH1A1 | |
| SCHEMBL536111 | 0.84 | DHODH (0.59) | DHODHKDM4ERAB9AHDAC6ALDH1A1 | |
| SCHEMBL505990 | 0.83 | DHODH (0.57) | DHODHKDM4EHDAC6ALDH1A1HPGD | |
| SCHEMBL6840296 | 0.83 | RAB9A (0.56) | DHODHKDM4ERAB9APARP1ALDH1A1 | |
| SCHEMBL536112 | 0.82 | KDM4E (0.49) | DHODHKDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL696548 | 0.81 | DHODH (0.56) | DHODHKDM4ERAB9APARP1ALDH1A1 | |
| SCHEMBL505816 | 0.81 | DHODH (0.84) | DHODHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |