Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 4/20 | 0.59 |
| ▸ | P2RY4 | P51582 | 4/20 | 0.59 |
| ▸ | P2RY6 | Q15077 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.56 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | PNP | P00491 | 1/20 | 0.52 |
| ▸ | HINT1 | P49773 | 2/20 | 0.51 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.51 |
| ▸ | FPR2 | P25090 | 2/20 | 0.51 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deoxyguanosine SCHEMBL2498296 | 0.93 | POLB (0.57) | P2RY2P2RY4P2RY6LMNATHRB | |
| Guanosine SCHEMBL536141 | 0.91 | LMNA (0.69) | LMNATHRBMTORMDM2NCOA1 | |
| Guanosine SCHEMBL8524537 | 0.91 | HPGD (0.63) | P2RY2P2RY4P2RY6LMNAHPGD | |
| Guanosine SCHEMBL5027190 | 0.91 | HPGD (0.63) | P2RY2P2RY4P2RY6LMNAHPGD | |
| Guanosine SCHEMBL10528215 | 0.88 | F2 (0.64) | P2RY2P2RY4P2RY6LMNATHRB | |
| Guanosine SCHEMBL1983917 | 0.88 | LMNA (0.64) | P2RY2P2RY4P2RY6LMNATHRB | |
| Guanosine SCHEMBL11023852 | 0.86 | DTYMK (0.61) | P2RY2P2RY4P2RY6DNMT1FPR2 | |
| Deoxyguanosine SCHEMBL20445785 | 0.85 | POLB (0.67) | P2RY2P2RY4P2RY6LMNAPNP | |
| Guanosine SCHEMBL27546322 | 0.85 | ADORA3 (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| Guanosine SCHEMBL4874332 | 0.85 | DNMT1 (0.63) | P2RY2P2RY4P2RY6HPGDDNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080145372-A1 | Bioreductively-Activated Prodrugs | ANGIOGENE, PHARMACEUTICALS LIMITED (GB) | 2008-06-19 | — | — | US | disclosed |
| EP-1799698-A1 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | Angiogene Pharmaceuticals Limited (GB) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032921-A1 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | ANGIOGENE PHARMACEUTICALS LIMITED (GB) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080145372-A1 | Bioreductively-Activated Prodrugs | NME2, PNP, NUDT1 | P2RY2 150/4885P2RY4 610/4885P2RY6 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.