Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359842 | 0.86 | LMNA (0.33) | LMNAHPGDALDH1A1HTTCYP2C19 | |
| SCHEMBL5362184 | 0.72 | NPC1 (0.40) | LMNAHPGDALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5288067 | 0.68 | LOX (0.34) | — | |
| SCHEMBL5306313 | 0.68 | LOX (0.31) | — | |
| SCHEMBL5368956 | 0.66 | — | — | |
| SCHEMBL5304859 | 0.66 | NAMPT (0.33) | HPGDALDH1A1CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL564467 | 0.65 | ALDH1A1 (0.64) | LMNAHPGDALDH1A1HTTCYP2C19 | |
| SCHEMBL5297823 | 0.64 | KMT2A (0.35) | LMNAHPGDALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL5299127 | 0.63 | ADORA3 (0.32) | — | |
| SCHEMBL5299398 | 0.63 | KCNH3 (0.44) | LMNAALDH1A1SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007012724-A1 | 1,2,4-THIADIAZOLE DERIVATIVES ANTIFUNGAL COMPOUNDS, COMPOSITIONS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | CYTOMICS SYSTEMS (FR) | 2007-02-01 | — | — | WO | claimed |
| WO-2007012724-A1 | 1,2,4-THIADIAZOLE DERIVATIVES ANTIFUNGAL COMPOUNDS, COMPOSITIONS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | CYTOMICS SYSTEMS (FR) | 2007-02-01 | — | — | WO | disclosed |