Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 6/20 | 0.31 |
| ▸ | RAB9A | P51151 | 6/20 | 0.31 |
| ▸ | HTT | P42858 | 5/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | ATM | Q13315 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL536256 | 0.97 | TP53 (0.37) | TP53TBXAS1NPC1RAB9AHTT | |
| SCHEMBL537208 | 0.97 | TP53 (0.37) | TP53TBXAS1NPC1RAB9AHTT | |
| SCHEMBL7997897 | 0.97 | TP53 (0.37) | TP53TBXAS1NPC1RAB9AHTT | |
| SCHEMBL20465806 | 0.85 | TP53 (0.48) | TP53TBXAS1NPC1RAB9AHTT | |
| SCHEMBL28164781 | 0.82 | TP53 (0.34) | TP53NPC1RAB9AHTTLMNA | |
| SCHEMBL27458343 | 0.82 | TP53 (0.46) | TP53TBXAS1NPC1RAB9AHTT | |
| SCHEMBL691481 | 0.78 | TP53 (0.48) | TP53TBXAS1NPC1RAB9AHTT | |
| SCHEMBL7529371 | 0.72 | TP53 (0.39) | TP53TBXAS1NPC1RAB9AHTT | |
| SCHEMBL4623792 | 0.72 | PIM1 (0.41) | TP53TBXAS1LMNA | |
| SCHEMBL536585 | 0.72 | TP53 (0.39) | TP53TBXAS1NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329682-B2 | Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-12-11 | — | — | US | claimed |
| US-20100075952-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIES,THE PREPARATION AND THE PHARMCETICAL USE THEEOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD (CN) | 2010-03-25 | — | — | US | claimed |
| EP-2157093-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2010-02-24 | — | — | EP | claimed |
| EP-2414432-B1 | AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION | CHEVRON ORONITE CO (US) | 2017-05-31 | — | — | EP | disclosed |
| CN-104144930-B | New indolizine derivatives, method for preparing same and pharmaceutical compositions containing same | 瑟维尔实验室 | 2017-02-22 | — | — | CN | disclosed |
| US-9315595-B2 | Amine-terminated telechelic polymers and precursors thereto and methods for their preparation | CHEVRON ORONITE COMPANY LLC (US) | 2016-04-19 | — | — | US | disclosed |
| CN-102356114-B | Amine-terminated telechelic polymers and precursors thereto and methods for their preparation | CHEVRON ORONITE CO | 2014-06-25 | — | — | CN | disclosed |
| US-20140031497-A1 | AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2014-01-30 | — | — | US | disclosed |
| US-20130303518-A1 | Methods of Inhibiting the Catalytic Activity of a Protein Kinase and of Treating a Protein Kinase Related Disorder | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2013-11-14 | — | — | US | disclosed |
| US-8552122-B2 | Amine-terminated telechelic polymers and precursors thereto and methods for their preparation | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2013-10-08 | — | — | US | disclosed |
| US-8329682-B2 | Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-12-11 | — | — | US | disclosed |
| US-20120295903-A1 | FLAVIN DERIVATIVES | BLOUNT KENNETH F (US) | 2012-11-22 | — | — | US | disclosed |
| CN-102356114-A | Amine-terminated telechelic polymers and precursors thereto and methods for their preparation | CHEVRON ORONITE CO | 2012-02-15 | — | — | CN | disclosed |
| EP-2414432-A2 | AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION | Chevron Oronite Company LLC (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010117619-A2 | AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION | CHEVRON ORONITE COMPANY LLC (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20100249001-A1 | AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF SOUTHERN MISSISSIPPI | 2010-09-30 | — | — | US | disclosed |
| US-20100075952-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIES,THE PREPARATION AND THE PHARMCETICAL USE THEEOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD (CN) | 2010-03-25 | — | — | US | disclosed |
| EP-2157093-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2010-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295903-A1 | FLAVIN DERIVATIVES | BLVRB, FLAD1, FDPS | TP53 3810/4885TBXAS1 269/4885NPC1 4376/4885 |
| US-20100249001-A1 | AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION | TERT, TELO2, TSPO | TP53 3927/4885TBXAS1 90/4885NPC1 3879/4885 |
| US-20100075952-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIES,THE PREPARATION AND THE PHARMCETICAL USE THEEOF | MTOR, PKN2, MAP3K15 | TP53 1651/4885TBXAS1 912/4885NPC1 2900/4885 |
| US-20130303518-A1 | Methods of Inhibiting the Catalytic Activity of a Protein Kinase and of Treating a Protein Kinase Related Disorder | PRKACA, PACSIN2, PRKACB | TP53 2597/4885TBXAS1 1587/4885NPC1 1441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.