Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367904 | 0.81 | ME2 (0.56) | KDM4EPKMCHRM4MEN1KMT2A | |
| SCHEMBL6536256 | 0.79 | KDM4E (0.55) | KDM4EPKMCHRM4MEN1KMT2A | |
| SCHEMBL5368103 | 0.77 | TPSAB1 (0.71) | KDM4EPKMCHRM4HDAC3HDAC4 | |
| SCHEMBL5368399 | 0.77 | HDAC3 (0.53) | KDM4EPKMCHRM4HDAC3HDAC4 | |
| SCHEMBL5362915 | 0.75 | HDAC6 (0.60) | KDM4EPKMCHRM4HDAC3HDAC4 | |
| SCHEMBL5523321 | 0.75 | HDAC3 (0.51) | CHRM4MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL5521812 | 0.75 | HDAC3 (0.51) | CHRM4MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL5521806 | 0.75 | HDAC3 (0.51) | CHRM4MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL2400940 | 0.74 | ITGB3 (0.42) | KDM4EPKMMEN1KMT2AAPOBEC3A | |
| SCHEMBL5371009 | 0.74 | PKM (0.51) | KDM4EPKMCHRM4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |