SCHEMBL536616

SCHEMBL536616

N#CCCCCn1cccc1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.45
CA2 P00918 2/20 0.37
CA9 Q16790 2/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CSNK2A1 P68400 2/20 0.35
HSD17B10 Q99714 2/20 0.35
KDM4E B2RXH2 1/20 0.35
TSHR P16473 1/20 0.35
TP53 P04637 2/20 0.34
ALDH1A1 P00352 2/20 0.32
PKM P14618 1/20 0.32
CCNT1 O60563 1/20 0.32
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32
CDK9 P50750 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
CNR2 P34972 1/20 0.31
TBXAS1 P24557 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL537352 0.98 MAPT (0.43) MAPTCA2CA9CA12CA1
SCHEMBL536329 0.98 MAPT (0.43) MAPTCA2CA9CA12CA1
SCHEMBL537527 0.93 CA2 (0.41) MAPTCA2CA9CA12CA1
SCHEMBL536224 0.82
SCHEMBL20465806 0.79 TP53 (0.48) MAPTKDM4ETSHRTP53ALDH1A1
SCHEMBL27458343 0.76 TP53 (0.46) MAPTKDM4ETP53ALDH1A1TBXAS1
SCHEMBL2946530 0.73 TBXAS1 (0.67) TBXAS1
SCHEMBL691481 0.73 TP53 (0.48) MAPTKDM4ETSHRTP53ALDH1A1
SCHEMBL30678315 0.69
SCHEMBL59340 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2414432-B1 AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION CHEVRON ORONITE CO (US) 2017-05-31 EP disclosed
US-9315595-B2 Amine-terminated telechelic polymers and precursors thereto and methods for their preparation CHEVRON ORONITE COMPANY LLC (US) 2016-04-19 US disclosed
US-20140031497-A1 AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2014-01-30 US disclosed
US-8552122-B2 Amine-terminated telechelic polymers and precursors thereto and methods for their preparation THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2013-10-08 US disclosed
EP-2414432-A2 AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION Chevron Oronite Company LLC (US) 2012-02-08 EP disclosed
WO-2010117619-A2 AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION CHEVRON ORONITE COMPANY LLC (US) 2010-10-14 WO disclosed
US-20100249001-A1 AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION UNIVERSITY OF SOUTHERN MISSISSIPPI 2010-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100249001-A1 AMINE-TERMINATED TELECHELIC POLYMERS AND PRECURSORS THERETO AND METHODS FOR THEIR PREPARATION TERT, TELO2, TSPO MAPT 1063/4885CA2 3021/4885CA9 2991/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.