Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 4/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968073 | 0.85 | MME (0.59) | CTSLMMP1MMP3MMEMMP8 | |
| SCHEMBL17596164 | 0.79 | CAPN1 (0.46) | MMP1MMP3MMECAPN1MMP8 | |
| SCHEMBL20741006 | 0.78 | CTSK (0.48) | CTSLMMP1MMP3MMEMMP8 | |
| SCHEMBL20741008 | 0.78 | CTSK (0.48) | CTSLMMP1MMP3MMEMMP8 | |
| SCHEMBL29792845 | 0.76 | CTSK (0.68) | CTSLCAPN1 | |
| SCHEMBL25259821 | 0.76 | PSMB1 (0.49) | CTSLMMP1MMP3MMECAPN1 | |
| SCHEMBL20603581 | 0.76 | PSMB5 (0.50) | MMP1MMP3MMEMMP8MMP2 | |
| SCHEMBL30450002 | 0.76 | PSMB1 (0.49) | CTSLMMP1MMP3MMECAPN1 | |
| SCHEMBL6465336 | 0.76 | PSMB1 (0.49) | CTSLMMP1MMP3MMECAPN1 | |
| SCHEMBL5712419 | 0.75 | CAPN1 (0.54) | CTSLMMP1MMP3CAPN1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186564-B2 | Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-03-06 | — | — | US | disclosed |
| US-20040014093-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, Protease-42 | BRISTOL-MYERS SQUIBB COMPANY | 2004-01-22 | — | — | US | disclosed |
| US-20030114373-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, CAN-12, and variants thereof | BRISTOL-MYERS SQUIBB COMPANY | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014093-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, Protease-42 | CAPNS1, CAPN1, CAPN2 | CTSL 34/4885MMP1 661/4885MMP3 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.