Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246262 | 0.88 | MME (0.47) | MMELTA4HMMP1MMP3MEN1 | |
| SCHEMBL20741008 | 0.85 | CTSK (0.48) | MMEMMP1MMP3MMP2MMP7 | |
| SCHEMBL6465336 | 0.85 | PSMB1 (0.49) | MMEMMP1MMP3MMP9MMP8 | |
| SCHEMBL20741006 | 0.85 | CTSK (0.48) | MMEMMP1MMP3MMP2MMP7 | |
| SCHEMBL30450002 | 0.85 | PSMB1 (0.49) | MMEMMP1MMP3MMP9MMP8 | |
| SCHEMBL25259821 | 0.85 | PSMB1 (0.49) | MMEMMP1MMP3MMP9MMP8 | |
| SCHEMBL5366694 | 0.85 | CTSL (0.44) | MMELTA4HMMP1MMP3MEN1 | |
| SCHEMBL20603581 | 0.82 | PSMB5 (0.50) | MMEMMP1MMP3MMP2MMP7 | |
| SCHEMBL5712419 | 0.82 | CAPN1 (0.54) | MMP1MMP3MEN1KMT2AMMP2 | |
| Carbamic Acid SCHEMBL30450803 | 0.82 | CAPN1 (0.48) | MMEMMP1MMP3CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912601-B2 | SUPPRESSION OF IMMUNE RESPONSE VIA INHIBITION OF CATHEPSIN S | MASSACHUSETTS INST TECHNOLOGY (US) | 2008-11-05 | — | — | EP | disclosed |
| US-7427591-B2 | Suppression of immune response via inhibition of cathepsin S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-09-23 | — | — | US | disclosed |
| US-7285525-B2 | Suppression of immune response via inhibition of cathepsin S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-10-23 | — | — | US | disclosed |
| US-20050095248-A1 | Suppression of immune response via inhibition of cathepsin S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-05-05 | — | — | US | disclosed |
| US-20050080010-A1 | Suppression of immune response via inhibition of cathepsin S | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-04-14 | — | — | US | disclosed |
| EP-1400530-A1 | Suppression of immune response via inhibition of cathepsin S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0912601-B1 | SUPPRESSION OF IMMUNE RESPONSE VIA INHIBITION OF CATHEPSIN S | MASSACHUSETTS INST TECHNOLOGY (US) | 2003-11-26 | — | — | EP | disclosed |
| US-20030166534-A1 | Suppression of immune response via inhibition of cathepsin S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2003-09-04 | — | — | US | disclosed |
| US-6608030-B1 | Suppression of immune response via inhibition of cathepsin S | BRIGHAM & WOMEN'S HOSPITAL, INC. | 2003-08-19 | — | — | US | disclosed |
| EP-0912601-A1 | SUPPRESSION OF IMMUNE RESPONSE VIA INHIBITION OF CATHEPSIN S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997040066-A1 | SUPPRESSION OF IMMUNE RESPONSE VIA INHIBITION OF CATHEPSIN S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1997-10-30 | — | — | WO | disclosed |