SCHEMBL5367543

SCHEMBL5367543

[N-]=[N+]=CC(=O)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.71
MEN1 O00255 1/20 0.71
HTT P42858 1/20 0.71
KMT2A Q03164 1/20 0.71
HIF1A Q16665 1/20 0.71
CES2 O00748 2/20 0.53
CES1 P23141 2/20 0.53
CYP1A1 P04798 7/20 0.50
CYP1B1 Q16678 7/20 0.50
MAOB P27338 2/20 0.50
P4HB P07237 1/20 0.49
SRD5A2 P31213 1/20 0.47
NR4A1 P22736 1/20 0.46
NR4A2 P43354 1/20 0.46
NR4A3 Q92570 1/20 0.46
GSK3B P49841 2/20 0.46
PTPN1 P18031 1/20 0.46
TRPV1 Q8NER1 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8869550 0.83 ALDH1A1 (1.00) ALDH1A1MEN1HTTKMT2AHIF1A
SCHEMBL8869439 0.80 CES2 (0.59) ALDH1A1MEN1HTTKMT2AHIF1A
SCHEMBL9448908 0.79 ALDH1A1 (0.61) ALDH1A1MEN1HTTKMT2AHIF1A
SCHEMBL4607255 0.77 KMT2A (0.56) ALDH1A1MEN1HTTKMT2AHIF1A
SCHEMBL294902 0.76 CES2 (0.61) ALDH1A1CES2CES1CYP1A1CYP1B1
SCHEMBL2073722 0.75 ALDH1A1 (0.61) ALDH1A1MEN1HTTKMT2AHIF1A
SCHEMBL7228800 0.75 CES2 (0.59) CES2CES1CYP1A1CYP1B1MAOB
SCHEMBL9449020 0.75 ALDH1A1 (0.67) ALDH1A1MEN1HTTKMT2AHIF1A
SCHEMBL9448994 0.75 ALDH1A1 (0.61) ALDH1A1MEN1HTTKMT2AHIF1A
SCHEMBL28605102 0.75 ALDH1A1 (0.61) ALDH1A1MEN1HTTKMT2AHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509819-B2 Micro-nano structure-based super-hydrophobic fabric and preparation method therefor SOOCHOW UNIVERSITY (CN) 2025-12-30 US disclosed
US-20230416977-A1 MICRO-NANO STRUCTURE-BASED SUPER-HYDROPHOBIC FABRIC AND PREPARATION METHOD THEREFOR SOOCHOW UNIVERSITY (CN) 2023-12-28 US disclosed
CN-112878053-B Micro-nano structure based super-hydrophobic fabric and preparation method thereof 苏州大学 2022-03-15 CN disclosed
CN-112878053-A Micro-nano structure based super-hydrophobic fabric and preparation method thereof 苏州大学 2021-06-01 CN disclosed
EP-1546126-B1 PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES CENTRAL GLASS CO LTD (JP) 2007-11-21 EP disclosed
US-7189863-B2 Process for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivatives CENTRAL GLASS COMPANY, LIMITED (JP) 2007-03-13 US disclosed
US-20060128976-A1 Process for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivatives CENTRAL GLASS COMPANY, LIMITED (JP) 2006-06-15 US disclosed
US-7053248-B2 brominating a trifluoromethyl-substituted acetophenone with bromine in presence of acetalization agent that is an alkylene diol, reacting the brominated acetal with metal alkoxide thereby converting brominated acetal into ether, hydrolyzing ether in presence of acid catalyst to remove an acetal group CENTRAL GLASS COMPANY, LIMITED (JP) 2006-05-30 US disclosed
US-20050171363-A1 Process for producing trifluoromethyl- substituted 2- alkoxyacetophenone derivatives CENTRAL GLASS COMPANY, LIMITED (JP) 2005-08-04 US disclosed
EP-1546126-A1 PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES Central Glass Company, Limited (JP) 2005-06-29 EP disclosed
WO-2004014887-A1 PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES CENTRAL GLASS COMPANY, LIMITED (JP) 2004-02-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060128976-A1 Process for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivatives HACL2, BOLA2; BOLA2B, ADH5 ALDH1A1 100/4885MEN1 3250/4885HTT 4106/4885
US-20050171363-A1 Process for producing trifluoromethyl- substituted 2- alkoxyacetophenone derivatives HACL2, BOLA2; BOLA2B, ADH5 ALDH1A1 100/4885MEN1 3250/4885HTT 4106/4885
US-12509819-B2 Micro-nano structure-based super-hydrophobic fabric and preparation method therefor KIT, MYB, MAST1 ALDH1A1 477/4885MEN1 1248/4885HTT 4202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.