Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | GRN | P28799 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358296 | 0.76 | TSHR (0.36) | TSHRPOLBHPGDKDM4EGRN | |
| SCHEMBL27699409 | 0.73 | MEN1 (0.46) | TSHRPOLBHPGDMEN1KMT2A | |
| SCHEMBL12361462 | 0.70 | PTGS1 (0.58) | KDM4EKLKB1PTGS1ALDH1A1PDPK1 | |
| SCHEMBL12632315 | 0.64 | HPGD (0.65) | TSHRPOLBHPGDMEN1KMT2A | |
| SCHEMBL15148105 | 0.64 | GRN (0.48) | TSHRPOLBHPGDMEN1KMT2A | |
| SCHEMBL4134838 | 0.64 | GRN (0.74) | TSHRPOLBHPGDMEN1KMT2A | |
| SCHEMBL4227497 | 0.64 | RAB9A (0.36) | KMT2AKDM4EPTGS1ALDH1A1PDPK1 | |
| SCHEMBL4684515 | 0.63 | MEN1 (0.50) | POLBMEN1KMT2AGAAMAPT | |
| SCHEMBL2254928 | 0.63 | RXRA (0.47) | PTGS1 | |
| SCHEMBL8157722 | 0.62 | ALDH1A1 (0.61) | TSHRPOLBKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145349-A2 | SUBSTITUTED PYRROLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-12-21 | — | — | WO | disclosed |