SCHEMBL5368134

SCHEMBL5368134

NCCCCC(=O)[C@@H](N)CC(N)=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.43
NFKB1 P19838 1/20 0.43
GSR P00390 1/20 0.42
BLM P54132 3/20 0.41
KMT2A Q03164 3/20 0.41
NPSR1 Q6W5P4 2/20 0.41
LMNA P02545 2/20 0.41
THRB P10828 2/20 0.41
ALOX15 P16050 2/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
PLG P00747 1/20 0.41
SLC6A2 P23975 1/20 0.41
RECQL P46063 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CHRM2 P08172 1/20 0.41
CHRM4 P08173 1/20 0.41
CHRM1 P11229 1/20 0.41
PAOX Q6QHF9 1/20 0.40
DPP7 Q9UHL4 5/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24915510 0.85 ALOX15 (0.43) GSRBLMKMT2AALOX15CHRM2
SCHEMBL17305092 0.82 CES2 (0.48) KMT2AMEN1DPP7CYP1A2
SCHEMBL5369661 0.82 ALOX15 (0.52) CYP2D6NFKB1GSRBLMKMT2A
SCHEMBL28288550 0.80 CES2 (0.52) KMT2AMEN1CYP1A2
SCHEMBL19186295 0.80 CHRM2 (0.54) CYP2D6NFKB1GSRBLMKMT2A
SCHEMBL14301143 0.79 DDAH1 (0.41) KMT2AMEN1DPP7CYP1A2
SCHEMBL17029472 0.77 GSR (0.59) CYP2D6NFKB1GSRBLMKMT2A
Asparagine SCHEMBL28884540 0.74 GSR (0.56) NFKB1GSRBLMKMT2AALOX15
SCHEMBL8260805 0.74 DDAH1 (0.37) BLMKMT2AALOX15MEN1ALDH1A1
Asparagine SCHEMBL28884539 0.74 GSR (0.56) NFKB1GSRBLMKMT2AALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220054590-A1 PROTOXIN-II VARIANTS AND METHODS OF USE THEREOF JANSSEN BIOTECH, INC. 2022-02-24 US claimed
US-11083776-B2 Protoxin-II variants and methods of use JANSSEN BIOTECH, INC. (US) 2021-08-10 US claimed
US-20200054712-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2020-02-20 US claimed
US-10463714-B2 Protoxin-II variants and methods of use JANSSEN BIOTECH, INC. (US) 2019-11-05 US claimed
US-20160287666-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2016-10-06 US claimed
US-7279149-B2 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2007-10-09 US claimed
WO-2005042005-A1 AMINO ACID COMPOSITION WITH INCREASED BLOOD BRAIN BARRIER PERMEABILITY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2005-05-12 WO claimed
US-20050095201-A1 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2005-05-05 US claimed
US-20220054590-A1 PROTOXIN-II VARIANTS AND METHODS OF USE THEREOF JANSSEN BIOTECH, INC. 2022-02-24 US disclosed
US-20210363204-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2021-11-25 US disclosed
US-11083776-B2 Protoxin-II variants and methods of use JANSSEN BIOTECH, INC. (US) 2021-08-10 US disclosed
EP-3277304-B1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH INC (US) 2021-08-04 EP disclosed
US-20200054712-A1 PROTOXIN-II VARIANTS AND METHODS OF USE JANSSEN BIOTECH, INC. 2020-02-20 US disclosed
US-10463714-B2 Protoxin-II variants and methods of use JANSSEN BIOTECH, INC. (US) 2019-11-05 US disclosed
US-7279149-B2 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2007-10-09 US disclosed
US-7279149-B2 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2007-10-09 US disclosed
WO-2005042005-A1 AMINO ACID COMPOSITION WITH INCREASED BLOOD BRAIN BARRIER PERMEABILITY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2005-05-12 WO disclosed
WO-2005042005-A1 AMINO ACID COMPOSITION WITH INCREASED BLOOD BRAIN BARRIER PERMEABILITY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2005-05-12 WO disclosed
US-20050095201-A1 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2005-05-05 US disclosed
US-20050095201-A1 Amino acid composition with increased blood brain barrier permeability MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2005-05-05 US disclosed