Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.67 |
| ▸ | CA12 | O43570 | 4/20 | 0.64 |
| ▸ | CA1 | P00915 | 4/20 | 0.64 |
| ▸ | CA2 | P00918 | 4/20 | 0.64 |
| ▸ | CA7 | P43166 | 4/20 | 0.64 |
| ▸ | CA9 | Q16790 | 4/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329143 | 1.00 | CES2 (0.67) | CES2CA12CA1CA2CA7 | |
| Pyridine SCHEMBL11592894 | 0.85 | MKNK1 (0.56) | CES2CA12CA1CA2CA7 | |
| SCHEMBL1805264 | 0.83 | CES2 (0.50) | CES2CA12CA1CA2CA7 | |
| SCHEMBL10781901 | 0.81 | CA12 (0.64) | CES2CA12CA1CA2CA7 | |
| SCHEMBL1163541 | 0.81 | CA12 (0.64) | CES2CA12CA1CA2CA7 | |
| SCHEMBL29357695 | 0.80 | CES2 (0.73) | CES2CA12CA1CA2CA7 | |
| SCHEMBL39507 | 0.80 | CES2 (0.73) | CES2CA12CA1CA2CA7 | |
| SCHEMBL2156558 | 0.80 | CES2 (1.00) | CES2CA12CA1CA2CA7 | |
| SCHEMBL926368 | 0.79 | LCK (0.55) | CES2CA12CA1CA2CA7 | |
| SCHEMBL1526264 | 0.79 | MAPT (0.69) | CES2CA1CA2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294718-B2 | Synthesis of a 4-methylthiazole-4(S)-carboxylic acid compound | GENZYME CORPORATION (US) | 2007-11-13 | — | — | US | claimed |
| US-20050209462-A1 | Synthesis of benzimidate from benzoic acid | GENZYME CORPORATION (US) | 2005-09-22 | — | — | US | claimed |
| EP-1506162-A2 | SYNTHESIS OF BENZONITRILES AND BENZIMIDATES | Genzyme Corporation (US) | 2005-02-16 | — | — | EP | claimed |
| US-6846958-B2 | Synthesis of benzimidate from benzoic acid | GENZYME CORPORATION (US) | 2005-01-25 | — | — | US | claimed |
| US-20030236426-A1 | Synthesis of benzimidate from benzoic acid | GENZYME CORPORATION | 2003-12-25 | — | — | US | claimed |
| WO-2003097582-A2 | SYNTHESIS OF BENZONITRILES AND BENZIMIDATES | GENZYME CORPORATION (US) | 2003-11-27 | — | — | WO | claimed |
| US-7294718-B2 | Synthesis of a 4-methylthiazole-4(S)-carboxylic acid compound | GENZYME CORPORATION (US) | 2007-11-13 | — | — | US | disclosed |
| US-7285670-B2 | Synthesis of substituted thiazoline carboxylic acids | GENZYME CORPORATION (US) | 2007-10-23 | — | — | US | disclosed |
| US-20060217561-A1 | Synthesis of substituted thiazoline carboxylic acids | CHORGHADE MUKUND S | 2006-09-28 | — | — | US | disclosed |
| US-6982335-B2 | Synthesis of substituted thiazoline carboxylic acids | GENZYME CORPORATION (US) | 2006-01-03 | — | — | US | disclosed |
| US-20050209462-A1 | Synthesis of benzimidate from benzoic acid | GENZYME CORPORATION (US) | 2005-09-22 | — | — | US | disclosed |
| EP-1529037-A2 | SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | Genzyme Corporation (US) | 2005-05-11 | — | — | EP | disclosed |
| EP-1506162-A2 | SYNTHESIS OF BENZONITRILES AND BENZIMIDATES | Genzyme Corporation (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6846958-B2 | Synthesis of benzimidate from benzoic acid | GENZYME CORPORATION (US) | 2005-01-25 | — | — | US | disclosed |
| US-20040082796-A1 | Synthesis of substituted thiazoline carboxylic acids | GENZYME CORPORATION | 2004-04-29 | — | — | US | disclosed |
| US-20030236426-A1 | Synthesis of benzimidate from benzoic acid | GENZYME CORPORATION | 2003-12-25 | — | — | US | disclosed |
| WO-2003097582-A2 | SYNTHESIS OF BENZONITRILES AND BENZIMIDATES | GENZYME CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003097622-A2 | SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | GENZYME CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217561-A1 | Synthesis of substituted thiazoline carboxylic acids | CPN1, NACA, TMT1A | CES2 9/4885CA12 613/4885CA1 188/4885 |
| US-20050209462-A1 | Synthesis of benzimidate from benzoic acid | FTH1, CISD2, CISD1 | CES2 2309/4885CA12 990/4885CA1 1391/4885 |
| US-20030236426-A1 | Synthesis of benzimidate from benzoic acid | FTH1, CISD2, CISD1 | CES2 2309/4885CA12 990/4885CA1 1391/4885 |
| US-20040082796-A1 | Synthesis of substituted thiazoline carboxylic acids | CPN1, NAT1, ME1 | CES2 13/4885CA12 886/4885CA1 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.