Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910033 | 0.84 | PDE9A (0.42) | CYP11B2CYP11B1EGLN2DHODHALDH1A1 | |
| SCHEMBL2154193 | 0.76 | CYP11B2 (0.53) | CYP11B2CYP11B1EGLN2ALDH1A1PDE3B | |
| SCHEMBL4909930 | 0.76 | AR (0.44) | CYP11B2DHODHALDH1A1CYP2A6 | |
| SCHEMBL4918458 | 0.74 | PIN1 (0.47) | ALDH1A1HPGD | |
| SCHEMBL14154943 | 0.71 | PDE9A (0.41) | DHODHKDM4EALDH1A1HPGD | |
| SCHEMBL6469589 | 0.70 | IMPDH2 (0.42) | KDM4EALDH1A1HPGD | |
| SCHEMBL7634772 | 0.70 | ALDH1A1 (0.48) | CYP11B2CYP11B1EGLN2ALDH1A1PDE3B | |
| SCHEMBL17021988 | 0.69 | CYP11B2 (0.41) | CYP11B2CYP11B1EGLN2ALDH1A1CYP2A6 | |
| SCHEMBL17021842 | 0.69 | APP (0.40) | CYP11B2CYP11B1EGLN2ALDH1A1CYP2A6 | |
| SCHEMBL14926516 | 0.68 | CYP11B2 (0.47) | CYP11B2CYP11B1EGLN2ALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145349-A2 | SUBSTITUTED PYRROLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007145349-A2 | SUBSTITUTED PYRROLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-12-21 | — | — | WO | disclosed |