Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 5/20 | 0.35 |
| ▸ | NPY1R | P25929 | 3/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14861006 | 0.85 | ANPEP (0.40) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL7860951 | 0.85 | ANPEP (0.40) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL537113 | 0.84 | MC4R (0.40) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL28896045 | 0.78 | MMP9 (0.41) | EPHX2METAP2METAP1MC4RMC5R | |
| SCHEMBL27913206 | 0.77 | ANPEP (0.43) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL27913200 | 0.77 | ANPEP (0.43) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL1673135 | 0.76 | MC4R (0.38) | NPY4RNPY1RNPY2RNPY5REPHX2 | |
| SCHEMBL27797839 | 0.76 | MC4R (0.38) | NPY4RNPY1RNPY2RNPY5REPHX2 | |
| SCHEMBL5636527 | 0.74 | ALPI (0.40) | ANPEPRNPEPDNPEPNPY4RNPY1R | |
| SCHEMBL27664365 | 0.74 | MC4R (0.37) | ANPEPRNPEPDNPEPNPY4RNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946422-B2 | 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents | ACHILLION PHARMACEUTICALS, INC. (US) | 2015-02-03 | — | — | US | disclosed |
| EP-2414368-B1 | HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS INC (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2013096785-A1 | 2-SUBSTITUTED-THIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | WO | disclosed |
| US-20130165471-A1 | 2-SUBSTITUTED-THIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS INC. (US) | 2013-06-27 | — | — | US | disclosed |
| EP-1664062-B1 | ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS INC (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20120114601-A1 | NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-8173636-B2 | Hydroxylthienoquinolones and related compounds as anti-infective agents | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20120040959-A1 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-8114888-B2 | Isothiazoloquinolones and related compounds as anti-infective agents | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| EP-2414368-A2 | HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | Achillion Pharmaceuticals, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2006118605-A2 | 8A, 9-DIHYDRO-4A-H-ISOTHIAZOLO[5,4-B] QUINOLINE-3, 4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2006-11-09 | — | — | WO | disclosed |
| US-20060235041-A1 | New isothiazoloquinolones and related compounds as anti-infective agents | ACHILLION PHARMACEUTICALS, INC. | 2006-10-19 | — | — | US | disclosed |
| WO-2006089054-A1 | NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006084053-A1 | 8-N-SUBSTITUTED-2H-ISOTHIAZOLO[5,4-B]QUINOLIZINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTIINFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173026-A1 | 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents | ACHILLION PHARMACEUTICALS, INC. | 2006-08-03 | — | — | US | disclosed |
| WO-2006074317-A1 | 1-THIA-2,4A-DIAZA-CYCLOPENTA[B]NAPHTHALENE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |
| EP-1664062-A1 | ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | Achillion Pharmaceuticals, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060100215-A1 | 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | disclosed |
| US-20050075363-A1 | Isothiazoloquinolones and related compounds as anti-infective agents | ACHILLION PHARMACEUTICALS, INC. | 2005-04-07 | — | — | US | disclosed |
| WO-2005019228-A1 | ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165471-A1 | 2-SUBSTITUTED-THIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | RECQL, DDX5, QTRT2 | ANPEP 4136/4885RNPEP 3275/4885DNPEP 4477/4885 |
| US-20050075363-A1 | Isothiazoloquinolones and related compounds as anti-infective agents | TOP1, IRF3, RECQL | ANPEP 4496/4885RNPEP 4273/4885DNPEP 4621/4885 |
| US-20060173026-A1 | 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents | TOP1, TOP2A, DNA2 | ANPEP 3937/4885RNPEP 4142/4885DNPEP 3708/4885 |
| US-20060235041-A1 | New isothiazoloquinolones and related compounds as anti-infective agents | TOP1, RECQL, IRF3 | ANPEP 4453/4885RNPEP 4162/4885DNPEP 4604/4885 |
| US-20120114601-A1 | NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | TOP1, RECQL, IRF3 | ANPEP 4453/4885RNPEP 4162/4885DNPEP 4604/4885 |
| US-20120040959-A1 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | TOP1, TOP2B, DNA2 | ANPEP 4697/4885RNPEP 4072/4885DNPEP 4714/4885 |
| US-20060100215-A1 | 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents | RECQL, DNA2, REV1 | ANPEP 4458/4885RNPEP 3488/4885DNPEP 3926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.