Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392796 | 0.95 | KEAP1 (0.56) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL9224374 | 0.89 | FNTA (0.57) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL8166683 | 0.87 | KEAP1 (0.48) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL7395237 | 0.87 | HDAC1 (0.55) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL7393301 | 0.82 | ALDH1A1 (0.46) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL4981463 | 0.81 | CES1 (0.60) | ALDH1A1TDP1L3MBTL1HDAC8HDAC6 | |
| SCHEMBL10685859 | 0.80 | KEAP1 (0.56) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL8668103 | 0.78 | CES2 (0.46) | ALDH1A1TDP1L3MBTL1HDAC8HDAC6 | |
| SCHEMBL9427231 | 0.78 | ALDH1A1 (0.56) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 | |
| SCHEMBL6472972 | 0.78 | KEAP1 (0.54) | KEAP1ALDH1A1FFAR1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235688-B1 | Process for preparing histone deacetylase inhibitors and intermediates thereof | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2007-06-26 | — | — | US | disclosed |
| US-20070021612-A1 | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2007-01-25 | — | — | US | disclosed |
| US-20030203959-A1 | Novel modulators of potassium channels | 4SC AG (DE) | 2003-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203959-A1 | Novel modulators of potassium channels | HCN3, KCNN3, KCNN1 | KEAP1 1445/4885ALDH1A1 1220/4885FFAR1 193/4885 |
| US-20070021612-A1 | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof | HDAC1, HDAC11, HDAC2 | KEAP1 1119/4885ALDH1A1 674/4885FFAR1 1192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.