Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373381 | 0.79 | UTS2R (0.55) | TDP1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL5262685 | 0.79 | KDM4E (0.47) | CYP24A1TDP1TP53SMN1; SMN2LMNA | |
| SCHEMBL5263994 | 0.79 | NPC1 (0.60) | CYP24A1TDP1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL5261415 | 0.78 | P2RX7 (0.46) | SMN1; SMN2NPC1RAB9ATSHRMEN1 | |
| SCHEMBL5095558 | 0.78 | SMN1; SMN2 (0.63) | TP53ALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL5262774 | 0.78 | SLC6A9 (0.54) | TP53SMN1; SMN2NPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL5551493 | 0.77 | ALDH1A1 (0.62) | TP53ALDH1A1SMN1; SMN2HPGDLMNA | |
| Hydrochloric Acid SCHEMBL5551489 | 0.77 | ALDH1A1 (0.62) | TP53ALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL5266049 | 0.76 | RAB9A (0.60) | TP53ALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL5552009 | 0.76 | ALDH1A1 (0.60) | TP53ALDH1A1SMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |