Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264063 | 0.87 | PIM1 (0.44) | P2RX7HDAC2RAB9ANPC1 | |
| SCHEMBL5262202 | 0.87 | TRPV1 (0.45) | P2RX7HDAC2CNR1CNR2 | |
| SCHEMBL5261739 | 0.85 | NPC1 (0.61) | P2RX7RAB9ANPC1KCNA3HPGD | |
| SCHEMBL5261415 | 0.83 | P2RX7 (0.46) | P2RX7UTS2RRAB9ANPC1MEN1 | |
| SCHEMBL5261775 | 0.83 | NSD2 (0.52) | P2RX7MEN1KMT2AHPGDANO1 | |
| SCHEMBL5262900 | 0.82 | NSD2 (0.45) | P2RX7MEN1KMT2AHPGDDRD4 | |
| SCHEMBL5262774 | 0.81 | SLC6A9 (0.54) | P2RX7UTS2RRAB9ANPC1MEN1 | |
| SCHEMBL5373381 | 0.80 | UTS2R (0.55) | UTS2RRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5266049 | 0.79 | RAB9A (0.60) | RAB9ANPC1MEN1KMT2AHPGD | |
| SCHEMBL5262921 | 0.78 | ALDH1A1 (0.62) | P2RX7RAB9ANPC1KMT2AKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |