Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12405937 | 0.88 | MAOA (0.55) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL20100784 | 0.79 | MAOA (0.50) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL8034552 | 0.75 | ESR1 (0.53) | DRD2CYP2C9TSHRDRD3HIF1A | |
| SCHEMBL13049833 | 0.75 | ESR1 (0.53) | DRD2CYP2C9TSHRDRD3HIF1A | |
| SCHEMBL30042409 | 0.74 | HTR2C (0.35) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL7938058 | 0.74 | MAOA (1.00) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL13853486 | 0.74 | DRD2 (0.53) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL1627427 | 0.74 | MAOA (1.00) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL29740683 | 0.74 | MAOA (1.00) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL29476085 | 0.74 | MAOA (1.00) | MAOADRD2KDM4ECYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235519-B2 | 1,2-substituted 2,3-dehydro-1H-5,9-dioxyacyclohepta[f]inden-7-ones and 7-substituted benzo[b]dioxepin-3-ones | GIVAUDAN SA (CH) | 2007-06-26 | — | — | US | disclosed |
| US-7022664-B2 | 1,2 Substituted 2,3-dihydro-1H-5,9 dioxacyclohepta[F]indden-7-ones and 7-substituted benzo[B][1,4]dioxepin-3-ones | GIVAUDAN SA (CH) | 2006-04-04 | — | — | US | disclosed |
| US-20050288518-A1 | 1,2-Substituted 2,3-dehydro-1H-5,9-dioxyacyclohepta[f]inden-7-ones and 7-substituted benzo[b]dioxepin-3-ones | GIVAUDAN SA (CH) | 2005-12-29 | — | — | US | disclosed |
| US-20030207788-A1 | 1,2 Substituted 2,3-dihydro- 1H-5,9 dioxacyclohepta[F]indden-7-ones and 7-substituted benzo[B][1,4]dioxepin-3 ones | GIVADUAN SA, CHEMIN DE LA PARFUMERIE (CH) | 2003-11-06 | — | — | US | disclosed |
| EP-1136481-B1 | 1,2-Substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones | GIVAUDAN SA (CH) | 2002-11-13 | — | — | EP | disclosed |
| US-20010044407-A1 | Use in fragrance compositions; marine odor | GIVAUDAN SA (CH) | 2001-11-22 | — | — | US | disclosed |
| EP-1136481-A1 | 1,2-Substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones | Givaudan SA (CH) | 2001-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207788-A1 | 1,2 Substituted 2,3-dihydro- 1H-5,9 dioxacyclohepta[F]indden-7-ones and 7-substituted benzo[B][1,4]dioxepin-3 ones | CYP1B1, CYP1A1, CYP4B1 | MAOA 1130/4885DRD2 303/4885KDM4E 873/4885 |
| US-20010044407-A1 | Use in fragrance compositions; marine odor | OPRD1, TRPA1, DBN1 | MAOA 2489/4885DRD2 485/4885KDM4E 1764/4885 |
| US-20050288518-A1 | 1,2-Substituted 2,3-dehydro-1H-5,9-dioxyacyclohepta[f]inden-7-ones and 7-substituted benzo[b]dioxepin-3-ones | CYP1B1, CYP1A1, SULT1E1 | MAOA 443/4885DRD2 495/4885KDM4E 871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.