Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.50 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.49 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.47 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.47 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325234 | 0.86 | ORAI1 (0.67) | PTGS2TP53ORAI1THRBMAPT | |
| SCHEMBL25251421 | 0.78 | THRB (0.48) | PTGS2TP53ORAI1THRBMAPT | |
| SCHEMBL7314655 | 0.78 | ORAI1 (0.81) | TP53ORAI1THRBMAPTCRACR2A | |
| SCHEMBL8955949 | 0.78 | PTGS2 (0.77) | PTGS2 | |
| SCHEMBL22842672 | 0.78 | ORAI1 (0.59) | PTGS2TP53ORAI1THRBMAPT | |
| SCHEMBL31420366 | 0.77 | PTGS2 (0.58) | PTGS2ORAI1MAPTCRACR2APDPK1 | |
| SCHEMBL6013902 | 0.77 | PTGS2 (0.77) | PTGS2TSHRPDPK1 | |
| SCHEMBL538151 | 0.76 | PTGS2 (0.51) | PTGS2PDPK1 | |
| SCHEMBL537395 | 0.76 | PTGS1 (0.65) | PTGS2TP53MAPTSMN1; SMN2KCNJ6 | |
| SCHEMBL25729256 | 0.76 | CDK8 (0.62) | PTGS2TRPC3KCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990336-B1 | PROCESS FOR PRODUCTION OF 5-ALKOXY-4-HYDROXYMETHYLPYRAZOLE COMPOUND | IHARA CHEMICAL IND CO (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-7812175-B2 | Process for production of 5-alkoxy-4-hydroxymethylpyrazole compound | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-10-12 | — | — | US | disclosed |
| US-7488831-B2 | Process for producing 5-hydroxy-4-thiomethylpyrazole compound | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-02-10 | — | — | US | disclosed |
| US-20090036688-A1 | Process for Production of 5-Alkoxy-4-Hydroxymethylpyrazole Compound | IHARA CHEMICAL INDUSTRY CO., LTD (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1990336-A1 | PROCESS FOR PRODUCTION OF 5-ALKOXY-4-HYDROXYMETHYLPYRAZOLE COMPOUND | Ihara Chemical Industry Co., Ltd. (JP) | 2008-11-12 | — | — | EP | disclosed |
| US-20070185334-A1 | Process for producing 5-hydroxy-4-thiomethylpyrazole compound | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-08-09 | — | — | US | disclosed |
| EP-1767528-A1 | PROCESS FOR PRODUCING 5-HYDROXY-4-THIOMETHYLPYRAZOLE COMPOUND | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2007-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036688-A1 | Process for Production of 5-Alkoxy-4-Hydroxymethylpyrazole Compound | CYP4F3, ADH5, CYP3A4 | PTGS2 1612/4885TP53 3793/4885ORAI1 4128/4885 |
| US-20070185334-A1 | Process for producing 5-hydroxy-4-thiomethylpyrazole compound | CYP3A5, CYP4F11, GTF3C5 | PTGS2 413/4885TP53 2939/4885ORAI1 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.