Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.53 |
| ▸ | PREP | P48147 | 3/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5326054 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL14646671 | 0.83 | FKBP1A (0.56) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL8329198 | 0.83 | PREP (0.56) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL82714 | 0.83 | PREP (0.62) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL25756732 | 0.83 | FKBP1A (0.56) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL630241 | 0.83 | PREP (0.62) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL630208 | 0.83 | PREP (0.62) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL4985728 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL30581660 | 0.83 | FKBP1A (0.53) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL30612198 | 0.83 | FKBP1A (0.53) | SMN1; SMN2NPC1RAB9AFKBP1APREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869052-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006106326-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |