Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.53 |
| ▸ | PREP | P48147 | 3/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5326054 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL5376822 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL8329198 | 0.83 | PREP (0.56) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL630241 | 0.83 | PREP (0.62) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL82714 | 0.83 | PREP (0.62) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL25756732 | 0.83 | FKBP1A (0.56) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL14646671 | 0.83 | FKBP1A (0.56) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL630208 | 0.83 | PREP (0.62) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL7650461 | 0.82 | PREP (0.61) | SMN1; SMN2NPC1RAB9AFKBP1APREP | |
| SCHEMBL7648948 | 0.82 | PREP (0.61) | SMN1; SMN2NPC1RAB9AFKBP1APREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390803-B2 | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| EP-1558243-A4 | TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20060116421-A1 | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2006-06-01 | — | — | US | disclosed |
| EP-1558243-A2 | TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041161-A2 | TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116421-A1 | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity | CCR2, CCR1, CCR9 | SMN1; SMN2 4030/4885NPC1 1688/4885RAB9A 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.