Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28219844 | 0.90 | SMN1; SMN2 (0.57) | PREPSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5326054 | 0.84 | SMN1; SMN2 (0.55) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL25756732 | 0.83 | FKBP1A (0.56) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL5376822 | 0.83 | SMN1; SMN2 (0.53) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL4985728 | 0.83 | SMN1; SMN2 (0.53) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL630241 | 0.83 | PREP (0.62) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL630208 | 0.83 | PREP (0.62) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL82714 | 0.83 | PREP (0.62) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL14646671 | 0.83 | FKBP1A (0.56) | PREPSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL7648948 | 0.82 | PREP (0.61) | PREPSMN1; SMN2NPC1RAB9AFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901489-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044339-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-11-27 | — | — | WO | disclosed |