Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 9/20 | 0.55 |
| ▸ | ATP4B | P51164 | 9/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.55 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | FASN | P49327 | 1/20 | 0.55 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.55 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29694095 | 1.00 | ATP4A (0.55) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL3179008 | 0.95 | ATP4A (0.51) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL3170087 | 0.94 | ATP4A (0.50) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL3177079 | 0.94 | ATP4A (0.50) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL3170408 | 0.94 | ATP4A (0.50) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL13846375 | 0.92 | CYP2C9 (0.65) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL29693616 | 0.92 | CYP2C9 (0.65) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL3177754 | 0.92 | CYP2C9 (0.48) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL14433017 | 0.90 | CYP2C9 (0.50) | ATP4AATP4BCYP2C9CYP3A4KDM4E | |
| SCHEMBL9527620 | 0.90 | ATP4A (0.55) | ATP4AATP4BCYP2C9CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111714639-A | Composition comprising histamine release-promoting substance and benzimidazole derivative | 黄泳华 | 2020-09-29 | — | — | CN | claimed |
| CN-109354587-B | Preparation method of pantoprazole sodium and pantoprazole sodium | 成都天台山制药有限公司 | 2020-09-18 | — | — | CN | claimed |
| CN-111084886-A | Composition comprising fatty acid or derivative thereof and benzimidazole derivative | 黄泳华 | 2020-05-01 | — | — | CN | claimed |
| US-9228216-B2 | Synthesis of prazole compounds | CODEXIS, INC. (US) | 2016-01-05 | — | — | US | claimed |
| US-20150056668-A1 | SYNTHESIS OF PRAZOLE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2015-02-26 | — | — | US | claimed |
| EP-2510089-A2 | SYNTHESIS OF PRAZOLE COMPOUNDS | Codexis, Inc. (US) | 2012-10-17 | — | — | EP | claimed |
| WO-2011071982-A2 | SYNTHESIS OF PRAZOLE COMPOUNDS | CODEXIS, INC. (US) | 2011-06-16 | — | — | WO | claimed |
| US-20080262043-A1 | Solid Crystalline Form of Pantoprazole Free Acid, Salts Derived Therefrom and Process for Their Preparation | MEDICHEM, S.A. (ES) | 2008-10-23 | — | — | US | claimed |
| US-20080004319-A1 | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole | BRAUDE VIVIANA | 2008-01-03 | — | — | US | claimed |
| US-7301030-B2 | Process for preparing (S)-pantoprazole | NYCOMED GMBH (DE) | 2007-11-27 | — | — | US | claimed |
| EP-1615913-A2 | PROCESS FOR PREPARING 2-(PYRIDINYL)METHYL SULFINYL-SUBSTITUTED BENZIMIDAZOLES AND NOVEL CHLORINATED DERIVATIVES OF PANTOPRAZOLE | Teva Pharmaceutical Industries Limited (IL) | 2006-01-18 | — | — | EP | claimed |
| EP-1575941-A2 | PROCESS FOR PREPARING (S)-PANTOPRAZOLE | Altana Pharma AG (DE) | 2005-09-21 | — | — | EP | claimed |
| US-20050075370-A1 | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole | TEVA PHARMACEUTICALS USA, INC. | 2005-04-07 | — | — | US | claimed |
| WO-2004111029-A2 | PROCESS FOR PREPARING 2-[(PYRIDINYL)METHYL]SULFINYL-SUBSTITUTED BENZIMIDAZOLES AND NOVEL CHLORINATED DERIVATIVES OF PANTOPRAZOLE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-12-23 | — | — | WO | claimed |
| EP-1270555-B1 | METHOD FOR OXIDIZING A THIOETHER GROUP INTO A SULFOXIDE GROUP | ESTEVE QUIMICA SA (ES) | 2004-08-25 | — | — | EP | claimed |
| WO-2004052881-A2 | PROCESS FOR PREPARING (S)-PANTOPRAZOLE | ALTANA PHARMA AG (DE) | 2004-06-24 | — | — | WO | claimed |
| US-6603009-B2 | Oxidation of a thioether to a sulfoxide using sodium percarbonate and a molybdenum salt as catalyst; making lansoprazole, omeprazole, rabeprazole, and pantoprazole | ESTEVE QUIMICA, S.A. (ES) | 2003-08-05 | — | — | US | claimed |
| US-20030028030-A1 | Method for oxidizing a thioether group into a sulfoxide group | ESTEVE QUIMICA, S.A. (ES) | 2003-02-06 | — | — | US | claimed |
| EP-1270555-A1 | METHOD FOR OXIDIZING A THIOETHER GROUP INTO A SULFOXIDE GROUP | ESTEVE QUIMICA, S.A. (ES) | 2003-01-02 | — | — | EP | claimed |
| EP-0166287-B1 | DIALKOXYRIDINES, PROCESS FOR THEIR PREPARATION, THEIR APPLICATION AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1989-08-23 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004319-A1 | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole | RAB29, SQOR, RAB35 | ATP4A 558/4885ATP4B 697/4885CYP2C9 20/4885 |
| US-20050075370-A1 | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole | RAB29, SQOR, RAB35 | ATP4A 558/4885ATP4B 697/4885CYP2C9 20/4885 |
| US-20030028030-A1 | Method for oxidizing a thioether group into a sulfoxide group | CBR1, CBR3, SCO2 | ATP4A 1886/4885ATP4B 2853/4885CYP2C9 493/4885 |
| US-20080262043-A1 | Solid Crystalline Form of Pantoprazole Free Acid, Salts Derived Therefrom and Process for Their Preparation | CYP3A43, SI, SENP6 | ATP4A 596/4885ATP4B 720/4885CYP2C9 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.