SCHEMBL5378571

SCHEMBL5378571

COc1ccc(C=C(C(=O)O)C(=O)O)c(OC)c1

nearest known ligand 0.74

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.59
ALDH1A1 P00352 3/20 0.59
MEN1 O00255 2/20 0.59
KMT2A Q03164 2/20 0.59
CYP1A2 P05177 8/20 0.58
CYP1A1 P04798 7/20 0.58
CYP1B1 Q16678 7/20 0.58
CYP3A4 P08684 1/20 0.57
CYP2C9 P11712 1/20 0.57
NPC1 O15118 2/20 0.55
RAB9A P51151 2/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
TNFRSF1A P19438 1/20 0.54
NFE2L2 Q16236 2/20 0.51
LY96 Q9Y6Y9 1/20 0.51
AKT1 P31749 1/20 0.50
MAPK1 P28482 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14462722 0.85 ALDH1A1 (0.58) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL15239442 0.82 HDAC8 (0.53) MAPT
SCHEMBL8649661 0.80 CYP1A2 (0.78) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL9360940 0.80 CYP1A2 (0.78) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL8131194 0.80 MAPT (0.68) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL10391013 0.80 JUN (0.55) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL10391015 0.80 JUN (0.55) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL27567539 0.79 CYP1A2 (0.66) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL4257971 0.77 ALDH1A1 (0.65) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL998236 0.77 LMNA (0.64) MAPTMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244776-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-07-17 US disclosed
US-20070100031-A1 Ultraviolet light absorbers RAVICHANDRAN RAMANATHAN 2007-05-03 US disclosed
US-7173128-B2 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-02-06 US disclosed
US-20040192684-A1 Ultraviolet light absorbers CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-30 US disclosed
EP-1430038-A1 ULTRAVIOLET LIGHT ABSORBERS Ciba SC Holding AG (CH) 2004-06-23 EP disclosed
WO-2003016292-A1 ULTRAVIOLET LIGHT ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-02-27 WO disclosed
US-5270313-A Treatment of circulatory disorders HOFFMANN-LA ROCHE INC. (US) 1993-12-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192684-A1 Ultraviolet light absorbers UNG, MSH6, MAL2 MAPT 904/4885ALDH1A1 131/4885MEN1 1937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.