Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 10/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28406484 | 0.78 | ALDH1A1 (0.44) | ALDH1A1GLATDP1HTR6LMNA | |
| SCHEMBL10474511 | 0.78 | HTR6 (0.60) | HTR6BCHE | |
| SCHEMBL5830880 | 0.78 | ALDH1A1 (0.51) | ALDH1A1GLATDP1HTR6LMNA | |
| SCHEMBL4891775 | 0.77 | ALDH1A1 (0.54) | ALDH1A1GLATDP1HTR6PKM | |
| SCHEMBL4900381 | 0.73 | ALDH1A1 (0.49) | ALDH1A1GLATDP1HTR6LMNA | |
| SCHEMBL5376311 | 0.72 | MTNR1B (0.45) | HTR6LMNAPSEN1PSEN2APH1B | |
| SCHEMBL27885302 | 0.72 | HTR6 (0.50) | TDP1HTR6LMNAPSEN1PSEN2 | |
| SCHEMBL4902058 | 0.71 | CYP1A2 (0.46) | ALDH1A1GLATDP1LMNACYP3A4 | |
| SCHEMBL6704543 | 0.70 | ALDH1A1 (0.55) | ALDH1A1GLATDP1HTR6LMNA | |
| SCHEMBL729501 | 0.69 | ALDH1A1 (0.65) | ALDH1A1GLATDP1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | claimed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | claimed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | claimed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | claimed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | claimed |
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-6777559-B2 | CYCLOCARBONYLATING ACETIC ACID (OR BENZOIC ACID)-1-(1-BENZENESULFONYL-1H-INDOL-2-YL)-ALLYL ESTER TO OBTAIN 9-BENZENESULFONYL-9H-CARBAZOL-4-YL ESTER; SAPONIFYING | HOFFMANN-LA ROCHE INC. | 2004-08-17 | — | — | US | disclosed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | disclosed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | disclosed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | ALDH1A1 1165/4885GLA 1810/4885TDP1 2793/4885 |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | ALDH1A1 1165/4885GLA 1810/4885TDP1 2793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.